Evidence map›Paper›PMID 26173503›Full record

ArticleDigestive diseases and sciences2015

Elevated Total Iron-Binding Capacity Is Associated with an Increased Risk of Celiac Disease.

Dorothea Letner, Joanna Peloquin, Jacquelyn Durand, Anna Rutherford, Vijay Yajnik, Hamed Khalili, John Garber

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In one paragraph

Article in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Dorothea LetnerGastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, Jackson 7, Boston, MA, 02114, USA. dletner@mgh.harvard.edu.
Joanna PeloquinGastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, Jackson 7, Boston, MA, 02114, USA. jpeloquin@mgh.harvard.edu.
Jacquelyn DurandGastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, Jackson 7, Boston, MA, 02114, USA. jdurand03@gmail.com.
Anna RutherfordDivision of Gastroenterology, Hepatology and Endoscopy, Brigham & Women's Hospital, 1620 Tremont Street, BC-3-002EE, Boston, MA, 02120, USA. arutherford@partners.org.
Vijay YajnikGastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, Jackson 7, Boston, MA, 02114, USA. vyajnik@mgh.harvard.edu.
Hamed KhaliliGastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, Jackson 7, Boston, MA, 02114, USA. hkhalili@mgh.harvard.edu.
John GarberGastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, Jackson 7, Boston, MA, 02114, USA. jjgarber@mgh.harvard.edu.
Massachusetts General Hospital · USBrigham and Women's Hospital · US

Funding

Oral Contraceptives in the Etiopathogenesis of Crohn's DiseaseK23DK099681 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KHALILI, HAMED · 2013 to 2017
$946k
Cytoskeletal regulation of intestinal barrier function and response to pathogensK08DK094966 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI GARBER, JOHN · 2012 to 2016
$801k
NIDDK NIH HHS K08 DK094966NIDDK NIH HHS K23 DK099681
6 · The paper itself

Abstract

backgroundSeveral lines of evidence suggest that abnormal iron homeostasis may itself play an important role in the development of celiac disease.

aimWe sought to determine whether abnormalities in iron status could be detected prior to the diagnosis of celiac disease, and to understand the relationship between altered iron indices and the natural history of celiac disease.

methodsWe conducted a case-control study at two major tertiary referral hospitals. Cases were comprised of patients with celiac disease in whom iron status was assessed prior to the diagnosis. Each case was matched to five controls without known gastrointestinal disease according to age and sex. Information on potential covariates and laboratory values within 1, 1-3, and 3-5 years prior to diagnosis was collected. We used conditional logistic regression to evaluate the effect of iron indices on risk of celiac disease.

resultsWe identified 157 celiac cases and 695 matched controls. Compared to participants with normal TIBC, the age-adjusted risk of celiac disease was significantly elevated among patients with elevated TIBC. For each 10 μg/dL increase in TIBC, the risk of celiac disease increased by 4.6, 3.8, and 7.9% within 1, 1-3, and 3-5 years prior to diagnosis, respectively. Patients with elevated pre-diagnosis TIBC were more likely to have abnormal liver enzymes and osteoporosis.

conclusionsElevated TIBC is associated with an increased risk of celiac disease. Further investigation into the potential role of altered iron homeostasis may uncover important environmental factors that contribute to the development of celiac disease.

Indexed as

Case-Control StudiesCeliac DiseaseFemaleHumansIronMaleMiddle AgedRetrospective StudiesRisk FactorsIronBiomarkersCeliac diseaseIron homeostasisTIBC

Identifiers

PMID26173503
OpenAlexW874927190

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.