ArticleAmerican journal of physiology. Endocrinology and metabolism2015
Pendrin localizes to the adrenal medulla and modulates catecholamine release.
Article in American journal of physiology. Endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Pendrin is upregulated by corticosterone and participates in its pressor response.American journal of physiology. Renal physiology · 2026Article
- Loss of OXGR1 function uncouples intrarenal RAS activation from pendrin and αENaC regulation and blunts angiotensin II-induced hypertension.Frontiers in pharmacology · 2026Article
- Dietary anions control potassium excretion: it is more than a poorly absorbable anion effect.American journal of physiology. Renal physiology · 2023Article
- Bicarbonate is the primary inducer of KCC3a expression in renal cortical B-type intercalated cells.American journal of physiology. Cell physiology · 2023Article
- Pendrin regulation is prioritized by anion in high-potassium diets.American journal of physiology. Renal physiology · 2023Article
- Pendrin-null mice develop severe hypokalemia following dietary NaAmerican journal of physiology. Renal physiology · 2022Article
- Regulation of Blood Pressure and Salt Balance By Pendrin-Positive Intercalated Cells: Donald Seldin Lecture 2020.Hypertension (Dallas, Tex. : 1979) · 2022Review
- The Renal Physiology of Pendrin-Positive Intercalated Cells.Physiological reviews · 2020Review
- Effects of extreme potassium stress on blood pressure and renal tubular sodium transport.American journal of physiology. Renal physiology · 2020Article
- Chromaffin Cells of the Adrenal Medulla: Physiology, Pharmacology, and Disease.Comprehensive Physiology · 2019Article
- Blood collection in unstressed, conscious, and freely moving mice through implantation of catheters in the jugular vein: a new simplified protocol.Physiological reports · 2018Article
- GABAPflugers Archiv : European journal of physiology · 2018Review
- Renal intercalated cells and blood pressure regulation.Kidney research and clinical practice · 2017Review
- Acute genetic ablation of pendrin lowers blood pressure in mice.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017Article
- Vascular contractile reactivity in hypotension due to reduced renal reabsorption of NaNaunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Pendrin-A New Target for Diuretic Therapy?Journal of the American Society of Nephrology : JASN · 2016Article
- Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide.Journal of the American Society of Nephrology : JASN · 2016Article
- Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- The role of pendrin in blood pressure regulation.American journal of physiology. Renal physiology · 2016Review
- The chloride-bicarbonate exchanger pendrin is increased in the kidney of the pregnant rat.Experimental physiology · 2015Article
Corrections and comments
- Erratum issuedCorrigendum.2015
Authors and funding
17 authors at 5 institutions in 1 country.
Funding
Abstract
Pendrin (Slc26a4) is a Cl(-)/HCO3 (-) exchanger expressed in renal intercalated cells and mediates renal Cl(-) absorption. With pendrin gene ablation, blood pressure and vascular volume fall, which increases plasma renin concentration. However, serum aldosterone does not significantly increase in pendrin-null mice, suggesting that pendrin regulates adrenal zona glomerulosa aldosterone production. Therefore, we examined pendrin expression in the adrenal gland using PCR, immunoblots, and immunohistochemistry. Pendrin protein was detected in adrenal lysates from wild-type but not pendrin-null mice. However, immunohistochemistry and qPCR of microdissected adrenal zones showed that pendrin was expressed in the adrenal medulla, rather than in cortex. Within the adrenal medulla, pendrin localizes to both epinephrine- and norepinephrine-producing chromaffin cells. Therefore, we examined plasma catecholamine concentration and blood pressure in wild-type and pendrin-null mice under basal conditions and then after 5 and 20 min of immobilization stress. Under basal conditions, blood pressure was lower in the mutant than in the wild-type mice, although epinephrine and norepinephrine concentrations were similar. Catecholamine concentration and blood pressure increased markedly in both groups with stress. With 20 min of immobilization stress, epinephrine and norepinephrine concentrations increased more in pendrin-null than in wild-type mice, although stress produced a similar increase in blood pressure in both groups. We conclude that pendrin is expressed in the adrenal medulla, where it blunts stress-induced catecholamine release.
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Registered trials
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