ArticleeLife2015
Self-recognition drives the preferential accumulation of promiscuous CD4(+) T-cells in aged mice.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance.Immunological reviews · 2025Review
- The aging of the immune system and its implications for transplantation.GeroScience · 2023Review
- Central tolerance is impaired in the middle-aged thymic environment.Aging cell · 2022Article
- Mechanisms underpinning poor antibody responses to vaccines in ageing.Immunology letters · 2022Review
- Single-cell profiling of immune system alterations in lymphoid, barrier and solid tissues in aged mice.Nature aging · 2022Article
- CD5 levels define functionally heterogeneous populations of naïve human CD4European journal of immunology · 2021Article
- Immunity to acute virus infections with advanced age.Current opinion in virology · 2021Review
- Age-Related Changes in Thymic Central Tolerance.Frontiers in immunology · 2021Review
- MAVS regulates the quality of the antibody response to West-Nile Virus.PLoS pathogens · 2020Article
- Why leveraging sex differences in immune trade-offs may illuminate the evolution of senescence.Functional ecology · 2020Review
- Role of Cell-Intrinsic and Environmental Age-Related Changes in Altered Maintenance of Murine T Cells in Lymphoid Organs.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice.PloS one · 2018Article
- Successful and Maladaptive T Cell Aging.Immunity · 2017Review
- Modelling T cell proliferation: Dynamics heterogeneity depending on cell differentiation, age, and genetic background.PLoS computational biology · 2017Article
- The life cycle of a T cell after vaccination - where does immune ageing strike?Clinical and experimental immunology · 2017Review
- Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus.PLoS pathogens · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
T-cell recognition of self and foreign peptide antigens presented in major histocompatibility complex molecules (pMHC) is essential for life-long immunity. How the ability of the CD4(+) T-cell compartment to bind self- and foreign-pMHC changes over the lifespan remains a fundamental aspect of T-cell biology that is largely unexplored. We report that, while old mice (18-22 months) contain fewer CD4(+) T-cells compared with adults (8-12 weeks), those that remain have a higher intrinsic affinity for self-pMHC, as measured by CD5 expression. Old mice also have more cells that bind individual or multiple distinct foreign-pMHCs, and the fold increase in pMHC-binding populations is directly related to their CD5 levels. These data demonstrate that the CD4(+) T-cell compartment preferentially accumulates promiscuous constituents with age as a consequence of higher affinity T-cell receptor interactions with self-pMHC.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.