ArticlePloS one2015
Obstruction of Venous Drainage Linked to Transient Global Amnesia.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- A familial case series of refractory head noise, tinnitus, and sleep disorders caused by internal jugular vein stenosis: illustrative cases.Journal of neurosurgery. Case lessons · 2026Article
- Cerebral blood flow alterations in non-auditory tinnitus: implications for cerebral venous congestion pathophysiology.Brain imaging and behavior · 2026Article
- Transient Global Amnesia and High-Grade Styloidogenic Jugular Vein Stenosis.JAMA network open · 2026Article
- Syndrome Sinistre: Left Brachiocephalic Vein Compression and its Neurological Manifestations.Neurology international · 2024Article
- Differential Assessment of Internal Jugular Vein Stenosis in Patients Undergoing CT and MRI with Contrast.Tomography (Ann Arbor, Mich.) · 2024Article
- A Perplexing case of isolated abducens nerve palsy in a primigravida woman: A case report.Case reports in women's health · 2023Article
- Stylohyoid Eagle syndrome and EXTracranial INternal Carotid arTery pseudoaneurysms (EXTINCT) with internal jugular vein nutcracker syndrome: a challenging clinical scenario.BMJ case reports · 2022Article
- Resolved Cerebral Venous Hypertension after Angioplasty of Central Venous Stenosis in a Hemodialysis Patient: A Case Report.Taehan Yongsang Uihakhoe chi · 2022Article
- Styloidogenic jugular venous compression syndrome: a case report and review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Review
- Probable factors affecting clinical outcomes of internal jugular vein stenosis.Annals of translational medicine · 2019Article
- Internal jugular vein stenosis induced by tortuous internal carotid artery compression: two case reports and literature review.The Journal of international medical research · 2019Review
- Internal jugular vein stenosis associated with elongated styloid process: five case reports and literature review.BMC neurology · 2019Review
- Transient Global Amnesia Linked to Impairment of Brain Venous Drainage: An Ultrasound Investigation.Frontiers in neurology · 2019Article
- Understanding jugular venous outflow disturbance.CNS neuroscience & therapeutics · 2018Review
- Simultaneous transient global amnesia and right MCA stroke after Valsalva manoeuvre.BMJ case reports · 2017Article
- Ultrasound diagnosis of transverse sinus hypoplasia using flow profiles of the internal jugular vein.PloS one · 2017Article
- Article
- Longitudinal Cerebral Perfusion Change in Transient Global Amnesia Related to Left Posterior Medial Network Disruption.PloS one · 2015Article
- Basilar Artery Embolism Mimicking Transient Global Amnesia in a 61-Year-Old Female: A Case Report.Case reports in neurologyArticle
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal extracranial venous drainage modality has been considered an etiology of transient global amnesia (TGA). Evidence suggests that the transmission of the intrathoracic/intraabdominal pressure during a Valsalva maneuver (VM) is mainly through the vertebral venous system, and patency of internal jugular vein (IJV) is essential for venous drainage and pressure releasing. We hypothesize that obstruction of IJV venous drainage is a contributing factor in TGA pathogenesis. A magnetic resonance (MR) imaging protocol was used in 45 TGA patients and 45 age- and sex-matched controls to assess the morphologies of IJV, brachiocephalic vein (BCV) and asymmetry of transverse sinus (TS). The IJV was divided into the upper- and middle-IJV segments. Compared to the controls, TGA patients had significantly higher rates of moderate and severe compression/stenosis at the bilateral upper-IJV segment (left: 37.8% vs. 17.8%, P = 0.0393; right: 57.8% vs.15.6%, P<0.0012), in left BCV (60% vs. 8.9%, P<0.0004), and in TS hypoplasia (53.3%% vs. 31.1%, P = 0.0405). The prevalence of at least one site of venous compression/stenosis in IJV or BCV was significantly higher in patients than in controls (91.1% vs. 33.3%, P<0.0004). The diameter of the left TS in MRV, but not in T1 contrast imaging, was significantly smaller in TGA patients than in controls (0.31 ± 0.21 vs. 0.41 ± 0.19, P = 0.0290), which was compatible with downstream venous stenosis/obstruction. TGA patients have a higher prevalence of compression/stenosis of the bilateral IJV and the left BCV and TS hypoplasia, which is new evidence that supports the role of extracranial veins in TGA pathogenesis.
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