Evidence map›Paper›PMID 26172457›Full record

ArticleOncotarget2015

EBV-encoded RNA via TLR3 induces inflammation in nasopharyngeal carcinoma.

Zhi Li, Yumei Duan, Shiyue Cheng, Yan Chen, Yanxin Hu, Lu Zhang, Jiang He, Qiong Liao, Lifang Yang, Lun-Quan Sun

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 66 citations in OpenAlex.

  1. Macrophages in oncoviral infections: from immune regulators to therapeutic targets.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Zhi LiCenter for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China 410008.
Yumei DuanCenter for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China 410008.
Shiyue ChengCenter for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China 410008.
Yan ChenCenter for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China 410008.
Yanxin HuCollege of Veterinary Medicine, China Agricultural University, Beijing, China 100193.
Lu ZhangCenter for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China 410008.
Jiang HeCenter for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China 410008.
Qiong LiaoCenter for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China 410008.
Lifang YangCenter for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China 410008.
Lun-Quan SunCenter for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China 410008.
Xiangya Hospital Central South University · CNCentral South University · CNChina Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogen-induced inflammation has been one of the intensive research areas in carcinogenesis. EBV encoded RNAs (EBERs) have been suggested to play roles in anti-apoptosis and growth-promotion in lymphoid and immune disorders. However, pathological roles of EBERs in solid tumors of epithelia origin remain to be elucidated. Given their characteristic dsRNA structures, recent studies provided evidences for the activation of some pattern recognition receptors (PRR) by EBERs, which is fundamental in the process of pathogenesis. Here, we show that EBERs induce inflammatory response in nasopharyngeal carcinoma (NPC) cells through Toll-like receptor 3 (TLR3), mainly featured by high level of TNFα production. Interestingly, EBERs and EBV latent membrane protein 1 (LMP1) form a positive regulatory loop with NF-κB as a key node that amplifies the inflammatory signals in EBV infected epithelial cells. We demonstrate in vivo that EBERs can interact with TLR3 and induce tumor cells to produce cytokines in B16 synergetic tumor and human NPC xenograft models, in which macrophages are recruited and activated, leading to a favorable microenvironment for solid tumor growth. Lastly, we verify a positive association between EBER and TNFα levels in NPC clinical samples and the combination of EBER and TNFα expressions provides a predictor of poor survival of NPC patients. In conclusion, EBERs play a pivotal role in inflammation-to-oncogenesis transition in NPC development.

Indexed as

Gene Expression Regulation, NeoplasticAnimalsApoptosisCarcinomaCell AdhesionCell Line, TumorCell Transformation, NeoplasticEpstein-Barr Virus InfectionsFemaleGene Expression Regulation, ViralHerpesvirus 4, HumanHumansInflammationMacrophagesMelanoma, ExperimentalMiceEBV-associated membrane antigen, Epstein-Barr virusNF-kappa BRNA, Double-StrandedRNA, ViralTLR3 protein, humanToll-Like Receptor 3Viral Matrix ProteinsEBV encoded RNAs (EBERs)inflammationnasopharyngeal carcinomaTLR3

Identifiers

PMID26172457
PMCPMC4695186
OpenAlexW1919992919

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.