ArticlePLoS computational biology2015
A Developmental Switch for Hebbian Plasticity.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Time Window of the Critical Period for Neuroplasticity in S1, V1, and A1 Sensory Areas of Small Rodents: A Systematic Review.Frontiers in neuroanatomy · 2022Pooled it
- Neonatal neuroplasticity and metaplasticity: bridging neuroscience to clinical practice.Pediatric research · 2026Review
- Neuronal identity is not static: An input-driven perspective.PLoS computational biology · 2025Article
- Information transfer and recovery for the sense of touch.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- A databank for intracellular electrophysiological mapping of the adult somatosensory cortex.GigaScience · 2018Article
- The role of spontaneous neurotransmission in synapse and circuit development.Journal of neuroscience research · 2018Review
- Anti-correlations in the degree distribution increase stimulus detection performance in noisy spiking neural networks.Journal of computational neuroscience · 2017Article
- Euchromatin histone methyltransferase 1 regulates cortical neuronal network development.Scientific reports · 2016Article
- Adaptive Spike Threshold Enables Robust and Temporally Precise Neuronal Encoding.PLoS computational biology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hebbian forms of synaptic plasticity are required for the orderly development of sensory circuits in the brain and are powerful modulators of learning and memory in adulthood. During development, emergence of Hebbian plasticity leads to formation of functional circuits. By modeling the dynamics of neurotransmitter release during early postnatal cortical development we show that a developmentally regulated switch in vesicle exocytosis mode triggers associative (i.e. Hebbian) plasticity. Early in development spontaneous vesicle exocytosis (SVE), often considered as 'synaptic noise', is important for homogenization of synaptic weights and maintenance of synaptic weights in the appropriate dynamic range. Our results demonstrate that SVE has a permissive, whereas subsequent evoked vesicle exocytosis (EVE) has an instructive role in the expression of Hebbian plasticity. A timed onset for Hebbian plasticity can be achieved by switching from SVE to EVE and the balance between SVE and EVE can control the effective rate of Hebbian plasticity. We further show that this developmental switch in neurotransmitter release mode enables maturation of spike-timing dependent plasticity. A mis-timed or inadequate SVE to EVE switch may lead to malformation of brain networks thereby contributing to the etiology of neurodevelopmental disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.