ArticleTranslational psychiatry2015
Alterations in circadian entrainment precede the onset of depression-like behavior that does not respond to fluoxetine.
Article in Translational psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Translational implications of circadian activity alterations in an experimental model of late-onset depression induced by prenatal excess of glucocorticoids.Frontiers in behavioral neuroscience · 2025Review
- Association of chronotype and depression symptoms in Chinese infertile population undergoing assisted reproductive technology.Frontiers in psychology · 2025Article
- Sex Differences in Long-term Outcome of Prenatal Exposure to Excess Glucocorticoids-Implications for Development of Psychiatric Disorders.Molecular neurobiology · 2023Article
- Circadian Clock Genes Are Regulated by Rhythmic Corticosterone at Physiological Levels in the Rat Hippocampus.Neuroendocrinology · 2023Article
- Patterns of activity correlate with symptom severity in major depressive disorder patients.Translational psychiatry · 2022Article
- Chronotype, circadian rhythm, and psychiatric disorders: Recent evidence and potential mechanisms.Frontiers in neuroscience · 2022Review
- Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease.International journal of molecular sciences · 2020Review
- Regulation of Circadian Genes by the MAPK Pathway: Implications for Rapid Antidepressant Action.Neuroscience bulletin · 2020Review
- Desipramine restores the alterations in circadian entrainment induced by prenatal exposure to glucocorticoids.Translational psychiatry · 2019Article
- Circadian regulation of depression: A role for serotonin.Frontiers in neuroendocrinology · 2019Review
- Faecal corticosterone metabolite assessment in socially housed male and female Wistar rats.Endocrine connections · 2018Article
- Redox unbalance modifies neurogenic potential.Oncotarget · 2017Article
- Transcription factor oscillations in neural stem cells: Implications for accurate control of gene expression.Neurogenesis (Austin, Tex.) · 2017Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growing evidence links adverse prenatal conditions to mood disorders. We investigated the long-term behavioral alterations induced by prenatal exposure to excess glucocorticoids (dexamethasone--DEX). At 12 months, but not earlier, DEX-exposed mice displayed depression-like behavior and impaired hippocampal neurogenesis, not reversible by the antidepressant fluoxetine (FLX). Concomitantly, we observed arrhythmic glucocorticoid secretion and absent circadian oscillations in hippocampal clock gene expression. Analysis of spontaneous activity showed progressive alterations in circadian entrainment preceding depression. Circadian oscillations in clock gene expression (measured by means of quantitative PCR) were also attenuated in skin fibroblasts before the appearance of depression. Interestingly, circadian entrainment is not altered in a model of depression (induced by methylmercury prenatal exposure) that responds to FLX. Altogether, our results suggest that alterations in circadian entrainment of spontaneous activity, and possibly clock gene expression in fibroblasts, may predict the onset of depression and the response to FLX in patients.
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