Trial reportPloS one2015
Sex Differences in Clinical Features of Early, Treated Parkinson's Disease.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cortisol levels, motor, cognitive and behavioral symptoms in Parkinson's disease: a systematic review.Journal of neural transmission (Vienna, Austria : 1996) · 2019Pooled it
- Altered habenular and whole brain functional connectivity in early Parkinson's disease using 7 T MRI.NPJ Parkinson's disease · 2025Article
- A report of the Iranian Parkinson's disease registry.NPJ Parkinson's disease · 2025Article
- Sex differences in the diagnosis latency of Parkinson's disease in Latin America.Parkinsonism & related disorders · 2025Article
- Gradients of Nigrostriatal Iron Deposition in Healthy Aging and Synucleinopathies.CNS neuroscience & therapeutics · 2025Article
- Spatiotemporal neurodegeneration of the substantia nigra and its connecting cortex and subcortex in Parkinson's disease.European journal of neurology · 2025Article
- Sex-dependent associations of serum BDNF, glycolipid metabolism and cognitive impairments in Parkinson's disease with depression: a comprehensive analysis.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- The role of autophagy in Parkinson's disease: a gender difference overview.Frontiers in pharmacology · 2024Review
- Association of women-specific health factors in the severity of Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson's Disease.Journal of clinical medicine · 2023Article
- Gender differences in motor and non-motor symptoms in individuals with mild-moderate Parkinson's disease.PloS one · 2023Article
- The quality of life in patients with Parkinson's disease: Focus on gender difference.Brain and behavior · 2022Article
- Contributions of sex, depression, and cognition on brain connectivity dynamics in Parkinson's disease.NPJ Parkinson's disease · 2021Article
- The Impact of Sex on the Neurocognitive Functions of Patients with Parkinson's Disease.Brain sciences · 2021Article
- TOMM40 '523' poly-T repeat length is a determinant of longitudinal cognitive decline in Parkinson's disease.NPJ Parkinson's disease · 2021Article
- Sex as an important factor in nanomedicine.Nature communications · 2021Review
- Cognitive Impairment in Parkinson's Disease: Epidemiology, Clinical Profile, Protective and Risk Factors.Behavioral sciences (Basel, Switzerland) · 2021Review
- Differential effects of sex on longitudinal patterns of cognitive decline in Parkinson's disease.Journal of neurology · 2021Article
- The Trajectory of Motor Deterioration to Death in Parkinson's Disease.Frontiers in neurology · 2021Article
- Is there a Neurobiological Rationale for the Utility of the Iowa Gambling Task in Parkinson's Disease?Journal of Parkinson's disease · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
introductionTo improve our understanding of sex differences in the clinical characteristics of Parkinson's Disease, we sought to examine differences in the clinical features and disease severity of men and women with early treated Parkinson's Disease (PD) enrolled in a large-scale clinical trial.
methodsAnalysis was performed of baseline data from the National Institutes of Health Exploratory Trials in Parkinson's Disease (NET-PD) Long-term Study-1, a randomized, multi-center, double-blind, placebo-controlled study of 10 grams of oral creatine/day in individuals with early, treated PD. We compared mean age at symptom onset, age at PD diagnosis, and age at randomization between men and women using t-test statistics. Sex differences in clinical features were evaluated, including: symptoms at diagnosis (motor) and symptoms at randomization (motor, non-motor, and daily functioning).
results1,741 participants were enrolled (62.5% male). No differences were detected in mean age at PD onset, age at PD diagnosis, age at randomization, motor symptoms, or daily functioning between men and women. Differences in non-motor symptoms were observed, with women demonstrating better performance compared to men on SCOPA-COG (Z = 5.064, p<0.0001) and Symbol Digit Modality measures (Z = 5.221, p<0.0001).
conclusionsOverall, men and women did not demonstrate differences in clinical motor features early in the course of PD. However, the differences observed in non-motor cognitive symptoms suggests further assessment of the influence of sex on non-motor symptoms in later stages of PD is warranted.
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Registered trials
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