ArticleParkinson's disease2015
Orbitofrontal (18) F-DOPA Uptake and Movement Preparation in Parkinson's Disease.
Article in Parkinson's disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Sleep improves accuracy, but not speed, of generalized motor learning in young and older adults and in individuals with Parkinson's disease.Frontiers in behavioral neuroscience · 2024Article
- Impact of cognition-related single nucleotide polymorphisms on brain imaging phenotype in Parkinson's disease.Neural regeneration research · 2023Article
- The role of the deep convolutional neural network as an aid to interpreting brain [European radiology · 2021Article
- The many facets of motor learning and their relevance for Parkinson's disease.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2017Review
- Learning "How to Learn": Super Declarative Motor Learning Is Impaired in Parkinson's Disease.Neural plasticity · 2017Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Parkinson's disease (PD) degeneration of mesocortical dopaminergic projections may determine cognitive and behavioral symptoms. Choice reaction time task is related to attention, working memory, and goal-directed behavior. Such paradigm involves frontal cortical circuits receiving mesocortical dopamine which are affected early in PD. The aim of this study is to characterize the role of dopamine on the cognitive processes that precede movement in a reaction time paradigm in PD. We enrolled 16 newly diagnosed and untreated patients with PD without cognitive impairment or depression and 10 control subjects with essential tremor. They performed multiple-choice reaction time task with the right upper limb and brain (18)F-DOPA PET/CT scan. A significant inverse correlation was highlighted between average reaction time and (18)F-DOPA uptake in the left lateral orbitofrontal cortex. No correlations were found between reaction time and PD disease severity or between reaction time and (18)F-DOPA uptake in controls. Our study shows that in PD, but not in controls, reaction time is inversely related to the levels of dopamine in the left lateral orbitofrontal cortex. This novel finding underlines the role of dopamine in the lateral orbitofrontal cortex in the early stages of PD, supporting a relation between the compensatory cortical dopamine and movement preparation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.