ArticleBiomedical reports2015
Magnesium prevents β-glycerophosphate-induced calcification in rat aortic vascular smooth muscle cells.
Article in Biomedical reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Effects of Magnesium Citrate, Magnesium Oxide, and Magnesium Sulfate Supplementation on Arterial Stiffness: A Randomized, Double-Blind, Placebo-Controlled Intervention Trial.Journal of the American Heart Association · 2022Trial
- A Randomized Trial of Magnesium Oxide and Oral Carbon Adsorbent for Coronary Artery Calcification in Predialysis CKD.Journal of the American Society of Nephrology : JASN · 2019Trial
- Association of serum magnesium levels and calcimimetic use: fractures and cardiovascular events in Japanese haemodialysis patients.Journal of bone and mineral metabolism · 2026Article
- Relationship between magnesium intake and decline in kidney function, incident chronic kidney disease and incident cardiovascular disease.Clinical kidney journal · 2025Article
- Unraveling the Mechanisms of Magnesium Supplementation in Alleviating Chronic Kidney Disease Complications and Progression: Balancing Risks and Benefits.Biological trace element research · 2025Review
- The Role of Iron and Other Micronutrients in Arterial Stiffness: Univariable and Multivariable Mendelian Randomization.Reviews in cardiovascular medicine · 2025Article
- Magnesium depletion scores as a risk factor for prevalence and mortality rates of urinary incontinence: a national survey analysis.Frontiers in nutrition · 2025Article
- Magnesium and Vascular Calcification in Chronic Kidney Disease: Current Insights.International journal of molecular sciences · 2024Review
- Serum Magnesium Levels and Cardiovascular Outcomes in Systolic Blood Pressure Intervention Trial Participants.Kidney medicine · 2023Article
- BMP-2 promotes fracture healing by facilitating osteoblast differentiation and bone defect osteogenesis.American journal of translational research · 2023Article
- Magnesium to prevent kidney disease-associated vascular calcification: crystal clear?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- Review
- Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches.Journal of molecular medicine (Berlin, Germany) · 2021Review
- Prevention of Vascular Calcification by Magnesium and Selected Polyphenols.Advances in preventive medicine · 2021Article
- Article
- Dietary magnesium supplementation improves lifespan in a mouse model of progeria.EMBO molecular medicine · 2020Article
- Review
- Inflammation and Vascular Calcification Causing Effects of Oxidized HDL are Attenuated by Adiponectin in Human Vascular Smooth Muscle Cells.International journal of molecular and cellular medicine · 2019Article
- Serum magnesium and risk of incident heart failure in older men: The British Regional Heart Study.European journal of epidemiology · 2018Article
- Magnesium prevents vascular calcification in vitro by inhibition of hydroxyapatite crystal formation.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vascular calcification (VC), in which high serum phosphate plays a critical role, is one major problem in patients with chronic kidney disease. Clinical studies report that magnesium has a protective effect on VC. However, the studies regarding the impact of high serum magnesium on VC at a cellular level are few and require further investigation. Therefore, the present study explored the effect of magnesium on calcification induced by β-glycerophosphate (BGP) in rat aortic vascular smooth muscle cells (RAVSMCs). In the present study, the addition of magnesium decreased calcium deposition, which was increased by BGP. Higher magnesium levels inhibited BGP-induced alkaline phosphatase (ALP) activity and decreased the expression of core-binding factor α-1 (Cbfα1). In conclusion, higher magnesium levels prevented BGP-induced calcification in RAVSMCs and inhibited the expression of Cbfα1 and ALP. Thus, magnesium is influencing the expression of Cbfα1 and ALP associated with VC and may have the potential to serve as a role for VC in clinical situations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.