Evidence map›Paper›PMID 26171167›Full record

ArticleBiomedical reports2015

Characteristic expression of

Sakiko Fujii, Katsumi Fujimoto, Noriko Goto, Masami Kanawa, Takeshi Kawamoto, Haiou Pan, Petcharin Srivatanakul, Waralak Rakdang, Juthamas Pornprasitwech, Tania Saskianti and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Biomedical reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Analysis of MSX1, RYK, NFκB p65, and CCL4 Proteins andInternational journal of molecular sciences · 2025
    Article
  2. Research progress on optimization ofFrontiers in bioengineering and biotechnology · 2024
    Review
  3. Article
  4. Review
  5. Laminin-Modified Dental Pulp Extracellular Matrix for Dental Pulp Regeneration.Frontiers in bioengineering and biotechnology · 2020
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Sakiko FujiiDepartment of Dental Science for Health Promotion, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima 734-8553, Japan.
Katsumi FujimotoDepartment of Dental and Medical Biochemistry, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima 734-8553, Japan.
Noriko GotoDepartment of Pediatric Dentistry, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima 734-8553, Japan.
Masami KanawaNatural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Hiroshima 734-8553, Japan.
Takeshi KawamotoDepartment of Dental and Medical Biochemistry, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima 734-8553, Japan.
Haiou PanTwo Cells Co., Ltd., Hiroshima, Hiroshima 734-8551, Japan.
Petcharin SrivatanakulBioEden Asia Co., Ltd., Klong Luang, Pathum Thani 12120, Thailand.
Waralak RakdangBioEden Asia Co., Ltd., Klong Luang, Pathum Thani 12120, Thailand.
Juthamas PornprasitwechBioEden Asia Co., Ltd., Klong Luang, Pathum Thani 12120, Thailand.
Tania SaskiantiDepartment of Pediatric Dentistry, Airlangga University, Surabaya, East Java 60132, Indonesia.
Ketut SuarditaDepartment of Conservative Dentistry, Airlangga University, Surabaya, East Java 60132, Indonesia.
Fusanori NishimuraDepartment of Dental Science for Health Promotion, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima 734-8553, Japan.
Yukio KatoDepartment of Dental and Medical Biochemistry, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima 734-8553, Japan.
Hiroshima University · JPAirlangga University · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dental pulp cells (DPCs) are a promising source of transplantable cells in regenerative medicine. However, DPCs have not been fully characterized at the molecular level. The aim of the present study was to distinguish DPCs from various source-derived mesenchymal stem cells (MSCs), fibroblasts (FBs) and other cells by the expression of several DPC-characteristic genes. DPCs were isolated from human pulp tissues by the explant method or the enzyme digestion method, and maintained with media containing 10% serum or 7.5% platelet-rich plasma. RNA was isolated from the cells and from dental pulp tissue specimens. The mRNA levels were determined by DNA microarray and quantitative polymerase chain reaction analyses. The msh homeobox 1, msh homeobox 2, T-box 2 and ectonucleoside triphosphate diphosphohydrolase 1 mRNA levels in DPCs were higher than that of the levels identified in the following cell types: MSCs derived from bone marrow, synovium and adipose tissue; and in cells such as FBs, osteoblasts, adipocytes and chondrocytes. The enhanced expression in DPCs was consistently observed irrespective of donor age, tooth type and culture medium. In addition, these genes were expressed at high levels in dental pulp tissue

Indexed as

dental pulp cellsfibroblastsgene expressionmesenchymal stem cellsregenerative medicine

Identifiers

PMID26171167
PMCPMC4487058
OpenAlexW2027877184

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.