ArticleMedical gas research2015
Hyperbaric oxygen in chronic traumatic brain injury: oxygen, pressure, and gene therapy.
Article in Medical gas research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Using the gross motor function measure evolution ratio to compare different dosage of hyperbaric treatment with conventional therapies in children with cerebral palsy - could it end the controversy?Frontiers in neurology · 2024Pooled it
- Systematic Review and Dosage Analysis: Hyperbaric Oxygen Therapy Efficacy in Mild Traumatic Brain Injury Persistent Postconcussion Syndrome.Frontiers in neurology · 2022Pooled it
- Hyperbaric oxygen therapy for mild traumatic brain injury persistent postconcussion syndrome: a randomized controlled trial.Medical gas researchTrial
- Continued confusion in mild traumatic brain injury hyperbaric oxygen studies.Contemporary clinical trials communications · 2024Article
- Clinical characteristics analysis of pediatric spinal cord injury without radiological abnormality in China: a retrospective study.BMC pediatrics · 2024Article
- Hydrogel in the Treatment of Traumatic Brain Injury.Biomaterials research · 2024Review
- Advances in hyperbaric oxygen to promote immunotherapy through modulation of the tumor microenvironment.Frontiers in oncology · 2023Review
- Hyperbaric Oxygen Therapy after Mid-Cervical Spinal Contusion Injury.Journal of neurotrauma · 2022Article
- Effect sizes for symptomatic and cognitive improvements in traumatic brain injury following hyperbaric oxygen therapy.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Effects of Hyperbaric Oxygen on T helper 17/regulatory T Polarization in Antigen and Collagen-induced Arthritis: Hypoxia-inducible Factor-1α as a Target.Oman medical journal · 2020Article
- Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis.BMJ open · 2018Article
- Effect of hyperbaric oxygenation therapy on post-concussion syndrome.Experimental and therapeutic medicine · 2018Review
- Therapeutic Potentials of Synapses after Traumatic Brain Injury: A Comprehensive Review.Neural plasticity · 2017Review
- Predictive Value of CTA Spot Sign on Hematoma Expansion in Intracerebral Hemorrhage Patients.BioMed research international · 2017Review
- New Beginnings forMedical gas research · 2016Article
- What's new inMedical gas researchArticle
- Co-administration of tissue plasminogen activator and hyperbaric oxygen in ischemic stroke: a continued promise for neuroprotection.Medical gas researchReview
- For the pursuit of oxygen and carbon dioxide channels in mitochondria.Medical gas researchArticle
- Molecular hydrogen: a therapeutic antioxidant and beyond.Medical gas researchReview
- Neuroprotective effect of hyperbaric oxygen therapy in a juvenile rat model of repetitive mild traumatic brain injury.Medical gas researchArticle
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperbaric oxygen therapy is a treatment for wounds in any location and of any duration that has been misunderstood for 353 years. Since 2008 it has been applied to the persistent post-concussion syndrome of mild traumatic brain injury by civilian and later military researchers with apparent conflicting results. The civilian studies are positive and the military-funded studies are a mixture of misinterpreted positive data, indeterminate data, and negative data. This has confused the medical, academic, and lay communities. The source of the confusion is a fundamental misunderstanding of the definition, principles, and mechanisms of action of hyperbaric oxygen therapy. This article argues that the traditional definition of hyperbaric oxygen therapy is arbitrary. The article establishes a scientific definition of hyperbaric oxygen therapy as a wound-healing therapy of combined increased atmospheric pressure and pressure of oxygen over ambient atmospheric pressure and pressure of oxygen whose main mechanisms of action are gene-mediated. Hyperbaric oxygen therapy exerts its wound-healing effects by expression and suppression of thousands of genes. The dominant gene actions are upregulation of trophic and anti-inflammatory genes and down-regulation of pro-inflammatory and apoptotic genes. The combination of genes affected depends on the different combinations of total pressure and pressure of oxygen. Understanding that hyperbaric oxygen therapy is a pressure and oxygen dose-dependent gene therapy allows for reconciliation of the conflicting TBI study results as outcomes of different doses of pressure and oxygen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.