ArticleGastroenterology and hepatology from bed to bench2015
The study of the oipA and dupA genes in Helicobacter pylori strains and their relationship with different gastroduodenal diseases.
Article in Gastroenterology and hepatology from bed to bench, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Association of Helicobacter pylori babA2 gene and gastric cancer risk: a meta-analysis.BMC cancer · 2020Pooled it
- Review
- Exploring virulence factors of Helicobacter pylori isolated from gastric biopsy.Molecular biology reports · 2024Article
- Pangenome Analysis ofInternational journal of genomics · 2024Article
- Frequency of significant virulence genes in gastric biopsies of Helicobacter pylori-positive patients with gastritis.AMB Express · 2023Article
- Is There a Real Relationship between the Presence ofInternational journal of microbiology · 2023Article
- Helicobacter pylori virulence dupA gene: risk factor or protective factor?Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Review
- Prevalence of Helicobacter pylori babA, oipA, sabA, and homB genes in isolates from Chinese patients with different gastroduodenal diseases.Medical microbiology and immunology · 2020Article
- Novel virulence factorWorld journal of gastroenterology · 2020Review
- Precancerous Gastric Lesions withBioMed research international · 2020Article
- Helicobacter pylori vacA, cagA and iceA genotypes in dyspeptic patients from southwestern region, Saudi Arabia: distribution and association with clinical outcomes and histopathological changes.BMC gastroenterology · 2019Article
- Prevalence and factors associated with H. pylori infection in Saudi patients with dyspepsia.Electronic physician · 2018Article
- Low Rate ofJournal of clinical and diagnostic research : JCDR · 2017Article
- Combination of OipA, BabA, and SabA as candidate biomarkers for predicting Helicobacter pylori-related gastric cancer.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe purpose of this investigation was to determine the oipA and dupA genes of Helicobacter pylori isolates from west of Iran; Chaharmahalo Bakhtiyari region and find their relationship with the severity of the gastroduodenal diseases.
backgroundHelicobacter pylori is an organism responsible for many gastroduodenal diseases. Many studies suggest that genetic diversity in H . pylori virulence factors such as oipA and dupA genes is high among isolates of different geographic regions and may cause more severe diseases. PATIENTS AND
methodsIn this cross-sectional study, gastric biopsy specimens were taken from 150 patients suffering from gastroduodenal diseases. The presence of ureC, dupA and oipA genes was tested by polymerase chain reaction (PCR).
resultsOverall, 123 (82%) H. pylori strains were isolated from 150 specimens. dupA gene was detected in 41 (33.33%) H.pylori-positive specimens. There was a reverse correlation between this gene and gastric cancer. The oipA gene was found in 88 (71.54%) samples and statistically there was no association between this gene and gastric disorders. As statistical analyses revealed, the presence of the dupA was more common in isolates with the oipA negative.
conclusionBased on our findings, the presence of dupA gene can be considered as a marker for the onset of severe diseases. However, the oipA gene cannot be regarded for prediction of gastroenterology diseases. Meanwhile, extended molecular epidemiology researches in other populations are recommended.
Indexed as
Identifiers
26171137PMC4495424W1952556462What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.