ArticleGastroenterology and hepatology from bed to bench2015
Milk of livestock as a possible transmission route of Helicobacter pylori infection.
Article in Gastroenterology and hepatology from bed to bench, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Assessment ofMicroorganisms · 2026Article
- On the Role of Food in the Transmission ofFoods (Basel, Switzerland) · 2025Review
- Detection ofOpen veterinary journal · 2025Article
- Review of foodborne helicobacteriosis.Italian journal of food safety · 2024Review
- Frequency and seasonality of viableItalian journal of food safety · 2023Article
- Isolation and identification ofItalian journal of food safety · 2022Article
- Research progress in theZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021Article
- Temperatures Outside the Optimal Range forBiology · 2021Article
- First report of PCR-based detection ofVeterinary world · 2020Article
- Novel virulence factorWorld journal of gastroenterology · 2020Review
- Ethyl acetate extract of Kaempferia parviflora inhibits Helicobacter pylori-associated mammalian cell inflammation by regulating proinflammatory cytokine expression and leukocyte chemotaxis.BMC complementary medicine and therapies · 2020Article
- Phenotypic and Genotypic Assessment of Antibiotic Resistance and Genotyping ofInfection and drug resistance · 2020Article
- Occurrence of cagAScientific reports · 2018Article
- First-time serological and molecular detection ofVeterinary world · 2018Article
- Review
- Phenotypic analysis of antibiotic resistance and genotypic study of theAntimicrobial resistance and infection control · 2018Article
- Review
- Role of food in environmental transmission ofCaspian journal of internal medicine · 2017Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe current investigation aimed to evaluate ruminant raw milk as a reservoir source of Helicobacter pylori and analyze the diversity of cagA and vacA genotypes as H. pylori virulence factors to find any relationship between these genotypes in human and animal H. pylori strains.
backgroundThe way of transmission of Helicobacter pylori as one of the most controversial bacteria in the world, which colonizes the human gastric tissue and is responsible for several gastric diseases is still unknown. The possibility of zoonotic transmission of H. pylori is feasible, but is not proven in ruminant reservoirs.
methodsOverall 210 cows, sheep, goats, camels and buffalos' raw milk samples and 100 human gastric biopsies were collected in this survey. We applied PCR assays to identify H. pylori, vacA and cagA genes. Statistical tests were applied for data analysis.
resultsTotally 12(16%) cow, 8(13.79%) sheep, 2 (4.76%) goat, 2(13.33%), buffalo 4(20%) and 82 (82%) of human specimens were confirmed to be H. pylori positive. Among which s1a/m2 genotype was more frequent in isolated H. pylori strains and statistically significant between strains. Based on statistical analyses the s1b allele of sheep had a significant association with human strains.
conclusionThe current survey was prompted by our previous report. According to both results we can conclude that sheep may act as a reservoir for H. pylori and transmit this bacterium to human via its milk. Extended assessments in other geographical regions and other animals are recommended.
Indexed as
Identifiers
26171135PMC4495422W1544585147What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.