Evidence map›Paper›PMID 26171115›Full record

ReviewOxidative medicine and cellular longevity2015

The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer's Disease.

Zhenzhen Liu, Tao Li, Ping Li, Nannan Wei, Zhiquan Zhao, Huimin Liang, Xinying Ji, Wenwu Chen, Mengzhou Xue, Jianshe Wei

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oxidative medicine and cellular longevity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06019117 (Effectiveness of a Probiotic K10 in Managing Health Outcomes in Parkinson's Disease and in Early Stage), which is not on this map. Cited by 92 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06019117 nacompletednot on this mapstarted 2023, after this paper: background citation

Effectiveness of a Probiotic K10 in Managing Health Outcomes in Parkinson's Disease and in Early Stage (Mild Cognitive Impairment to Mild Dementia) and Alzheimer's Disease

TypeinterventionalSponsorDeivis de Oliveira guimaraesRan2023 to 2024Enrolled104ConditionsParkinson Disease, Alzheimer DiseaseArmsProbiotic K10, Placebo
3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Autophagy-lysosomal pathway in neurodegeneration.Molecular neurodegeneration advances · 2026
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhenzhen LiuInstitute of Neuroscience, Henan Polytechnic University, Jiaozuo 454000, China ; Laboratory of Brain Function and Molecular Neurodegeneration, Institute for Brain Science Research, School of Life Sciences, Henan University, Kaifeng 475004, China.
Tao LiLaboratory of Brain Function and Molecular Neurodegeneration, Institute for Brain Science Research, School of Life Sciences, Henan University, Kaifeng 475004, China.
Ping LiLaboratory of Brain Function and Molecular Neurodegeneration, Institute for Brain Science Research, School of Life Sciences, Henan University, Kaifeng 475004, China.
Nannan WeiLaboratory of Brain Function and Molecular Neurodegeneration, Institute for Brain Science Research, School of Life Sciences, Henan University, Kaifeng 475004, China.
Zhiquan ZhaoLaboratory of Brain Function and Molecular Neurodegeneration, Institute for Brain Science Research, School of Life Sciences, Henan University, Kaifeng 475004, China.
Huimin LiangLaboratory of Brain Function and Molecular Neurodegeneration, Institute for Brain Science Research, School of Life Sciences, Henan University, Kaifeng 475004, China.
Xinying JiLaboratory of Brain Function and Molecular Neurodegeneration, Institute for Brain Science Research, School of Life Sciences, Henan University, Kaifeng 475004, China.
Wenwu ChenDepartment of Neurology, The First Affiliated Hospital, Henan University, Kaifeng 475000, China ; Institute of Neurological Disorder, Henan University, Kaifeng 475000, China.
Mengzhou XueDepartment of Neurology, The First Affiliated Hospital, Henan University, Kaifeng 475000, China ; Institute of Neurological Disorder, Henan University, Kaifeng 475000, China.
Jianshe WeiInstitute of Neuroscience, Henan Polytechnic University, Jiaozuo 454000, China ; Laboratory of Brain Function and Molecular Neurodegeneration, Institute for Brain Science Research, School of Life Sciences, Henan University, Kaifeng 475004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common form of dementia. The pathological hallmarks of AD are amyloid plaques [aggregates of amyloid-beta (Aβ)] and neurofibrillary tangles (aggregates of tau). Growing evidence suggests that tau accumulation is pathologically more relevant to the development of neurodegeneration and cognitive decline in AD patients than Aβ plaques. Oxidative stress is a prominent early event in the pathogenesis of AD and is therefore believed to contribute to tau hyperphosphorylation. Several studies have shown that the autophagic pathway in neurons is important under physiological and pathological conditions. Therefore, this pathway plays a crucial role for the degradation of endogenous soluble tau. However, the relationship between oxidative stress, tau protein hyperphosphorylation, autophagy dysregulation, and neuronal cell death in AD remains unclear. Here, we review the latest progress in AD, with a special emphasis on oxidative stress, tau hyperphosphorylation, and autophagy. We also discuss the relationship of these three factors in AD.

Indexed as

AutophagyOxidative StressAlzheimer DiseaseAntioxidantsHumansPhosphorylationReactive Oxygen Speciestau ProteinsAntioxidantsReactive Oxygen Speciestau Proteins

Identifiers

PMID26171115
PMCPMC4485995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.