Evidence map›Paper›PMID 26171113›Full record

Trial reportOxidative medicine and cellular longevity2015

Dexmedetomidine Analgesia Effects in Patients Undergoing Dental Implant Surgery and Its Impact on Postoperative Inflammatory and Oxidative Stress.

Sisi Li, Yang Yang, Cong Yu, Ying Yao, Yujia Wu, Lian Qian, Chi Wai Cheung

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Oxidative medicine and cellular longevity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04694300 (Demonstration of OTC Naproxen Sodium's), which is not on this map. Cited by 26 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 7 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04694300 phase4completednot on this mapstarted 2021, after this paper: background citation

Demonstration of OTC Naproxen Sodium's (Aleve's) Anti-inflammatory Action in Dental Implant Surgery Patients

TypeinterventionalSponsorHersh, Elliot V., DMD, MS, PhDRan2021 to 2022Enrolled30ConditionsOsseointegrated Dental Implantation, Pain, AcuteArmsNaproxen, Acetaminophen, Tramadol
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 7 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Sisi LiDepartment of Anesthesia, Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Stomatology Hospital of Chongqing Medical University, No. 426 Songshibeilu, Yubei District, Chongqing 401146, China.
Yang YangDepartment of Anesthesia, Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Stomatology Hospital of Chongqing Medical University, No. 426 Songshibeilu, Yubei District, Chongqing 401146, China.
Cong YuDepartment of Anesthesia, Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Stomatology Hospital of Chongqing Medical University, No. 426 Songshibeilu, Yubei District, Chongqing 401146, China.
Ying YaoDepartment of Anesthesia, Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Stomatology Hospital of Chongqing Medical University, No. 426 Songshibeilu, Yubei District, Chongqing 401146, China.
Yujia WuDepartment of Anesthesia, Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Stomatology Hospital of Chongqing Medical University, No. 426 Songshibeilu, Yubei District, Chongqing 401146, China.
Lian QianDuke-NUS Graduate Medical School Singapore, Singapore 169857.
Chi Wai CheungDepartment of Anesthesiology, The University of Hong Kong, Hong Kong.
Stomatological Hospital of Chongqing Medical University · CNDuke-NUS Medical School · SGUniversity of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the study was to determine whether or not dexmedetomidine- (DEX-) based intravenous infusion in dental implantation can provide better sedation and postoperative analgesia via suppressing postoperative inflammation and oxidative stress. Sixty patients were randomly assigned to receive either DEX (group D) or midazolam (group M). Recorded variables were vital sign (SBP/HR/RPP/SpO2/RR), visual analogue scale (VAS) pain scores, and observer's assessment of alertness/sedation scale (OAAS) scores. The plasma levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), antioxidant superoxide dismutase (SOD), and the lipid peroxidation product malondialdehyde (MDA) were detected at baseline and after 2, 4, and 24 h of drug administration. The VAS pain scores and OAAS scores were significantly lower for patients in group D compared to group M. The plasma levels of TNF-α, IL-6, and MDA were significantly lower in group D patients than those in group M at 2 h and 4 h. In group M, SOD levels decreased as compared to group D at 2 h and 4 h. The plasma levels of TNF-α, IL-6, and MDA were positively correlated with VAS pain scores while SOD negatively correlated with VAS pain scores. Therefore, DEX appears to provide better sedation during office-based artificial tooth implantation. DEX offers better postoperative analgesia via anti-inflammatory and antioxidation pathway.

Indexed as

Dental ImplantsAdultAnalgesics, Non-NarcoticDexmedetomidineEnzyme-Linked Immunosorbent AssayFemaleHumansHypnotics and SedativesInflammationInterleukin-6MaleMalondialdehydeMidazolamMiddle AgedOxidative StressPainAnalgesics, Non-NarcoticDental ImplantsDexmedetomidineHypnotics and SedativesIL6 protein, humanInterleukin-6MalondialdehydeMidazolamSuperoxide DismutaseTumor Necrosis Factor-alpha

Identifiers

PMID26171113
PMCPMC4485522
OpenAlexW1504572368

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.