Evidence map›Paper›PMID 26171017›Full record

ArticleOncology letters2015

Upregulation of H19 promotes invasion and induces epithelial-to-mesenchymal transition in esophageal cancer.

Cheng Huang, Lihua Cao, Limin Qiu, Xiaoli Dai, Linwei Ma, Yingting Zhou, Huifen Li, Min Gao, Weiyong Li, Qing Zhang and 2 more

Erratum issuedOpen access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. H19: An Oncogenic Long Non-coding RNA in Colorectal Cancer.The Yale journal of biology and medicine · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. LncRNA H19: A novel oncogene in multiple cancers.International journal of biological sciences · 2021
    Review
  11. Article
  12. Review
  13. [Effect of long chain non-coding RNA H19 on the migration and invasion of oral cancer cells and its molecular mechanism].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2019
    Article
  14. Article
  15. Article
  16. Article
  17. The Many Faces of Long Noncoding RNAs in Cancer.Antioxidants & redox signaling · 2018
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Cheng HuangDepartment of Clinical Medicine, Yancheng Institute of Health Sciences, Yancheng, Jiangsu 224005, P.R. China.
Lihua CaoDepartment of Dermatology, Yancheng City No. 1 People's Hospital, The Fourth Affiliated Hospital of Nantong Medical College, Yancheng, Jiangsu 224005, P.R. China.
Limin QiuDepartment of Thoracic Surgery, Yancheng City No. 1 People's Hospital, The Fourth Affiliated Hospital of Nantong Medical College, Yancheng, Jiangsu 224005, P.R. China.
Xiaoli DaiDepartment of Clinical Medicine, Yancheng Institute of Health Sciences, Yancheng, Jiangsu 224005, P.R. China.
Linwei MaDepartment of Clinical Medicine, Yancheng Institute of Health Sciences, Yancheng, Jiangsu 224005, P.R. China.
Yingting ZhouDepartment of Pathology, Yancheng Institute of Health Sciences, Yancheng, Jiangsu 224005, P.R. China.
Huifen LiDepartment of Pathology, Yancheng Institute of Health Sciences, Yancheng, Jiangsu 224005, P.R. China.
Min GaoDepartment of Clinical Medicine, Yancheng Institute of Health Sciences, Yancheng, Jiangsu 224005, P.R. China.
Weiyong LiDepartment of Clinical Medicine, Yancheng Institute of Health Sciences, Yancheng, Jiangsu 224005, P.R. China.
Qing ZhangDepartment of Clinical Medicine, Yancheng Institute of Health Sciences, Yancheng, Jiangsu 224005, P.R. China.
Koulan HanDepartment of Clinical Medicine, Yancheng Institute of Health Sciences, Yancheng, Jiangsu 224005, P.R. China.
Hongzhen LvDepartment of Pathology, Yancheng Institute of Health Sciences, Yancheng, Jiangsu 224005, P.R. China.
Yancheng Institute of Technology · CNYancheng Third People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) have previously been reported to be involved in cancer invasion, proliferation and apoptosis. However, the association between the lncRNA, H19, and esophageal cancer (EC) has remained elusive. In the present study, reverse transcription quantitative-polymerase chain reaction revealed that the expression of H19 was significantly increased and associated with tumor depth and metastasis in 133 EC samples. Furthermore, MTT and Transwell assays revealed that overexpression of H19

Indexed as

epithelial-to-mesenchymal transitionesophageal cancerH19invasionproliferation

Identifiers

PMID26171017
PMCPMC4487103
OpenAlexW2026010629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.