ArticleArchives of medical science : AMS2015
Association between inflammatory biomarkers and thin-cap fibroatheroma detected by optical coherence tomography in patients with coronary heart disease.
Article in Archives of medical science : AMS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Inflammatory Biomarkers Interleukin-6 and C-Reactive Protein and Outcomes in Stable Coronary Heart Disease: Experiences From the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) Trial.Journal of the American Heart Association · 2017 · on this mapTrial
- Association between triglyceride-glucose index and OCT-defined high-risk coronary plaques in stable angina.BMC cardiovascular disorders · 2026Article
- Interleukin-6 is associated with high-risk plaque on coronary computed tomography angiography in asymptomatic women.American journal of preventive cardiology · 2025Article
- Emerging Biomarkers and Electrochemical Biosensors for Early Detection of Premature Coronary Artery Disease.Diagnostics (Basel, Switzerland) · 2025Review
- Association and predictability of major perioperative cardiovascular adverse events and elevated neutrophil percentage-to-albumin ratio in patients with stable coronary artery disease undergoing non-cardiac surgery.Frontiers in cardiovascular medicine · 2025Article
- Pathophysiology of Acute Coronary Syndromes-Diagnostic and Treatment Considerations.Life (Basel, Switzerland) · 2023Review
- The Impact of Cytokines in Coronary Atherosclerotic Plaque: Current Therapeutic Approaches.International journal of molecular sciences · 2022Review
- Non-Invasive Modalities in the Assessment of Vulnerable Coronary Atherosclerotic Plaques.Tomography (Ann Arbor, Mich.) · 2022Review
- Association Between Dietary Intakes and Plaque Vulnerability Measured by Optical Coherence Tomography in Patients With Coronary Heart Disease: A Mediation Analysis of Inflammatory Factors.Frontiers in nutrition · 2022Article
- Influence of statin therapy on antiphospholipid antibodies and endothelial dysfunction in young patients with coronary artery disease and systemic lupus erythematosus.Archives of medical science : AMS · 2022Article
- Endothelial Dysfunction, Inflammation and Coronary Artery Disease: Potential Biomarkers and Promising Therapeutical Approaches.International journal of molecular sciences · 2021Review
- Association of Polyvascular Disease and Elevated Interleukin-6 With Outcomes in Acute Ischemic Stroke or Transient Ischemic Attack.Frontiers in neurology · 2021Article
- Combined non-invasive scan and biomarkers to identify independent risk factors in patients with mild coronary stenosis.Journal of thoracic disease · 2020Article
- Prevalence of high-risk coronary plaques in patients with and without metabolic syndrome and the relationship with prognosis.BMC cardiovascular disorders · 2020Article
- Observational
- Nuclear factor kappa B in patients with a history of unstable angina: case re-opened.Internal and emergency medicine · 2018Article
- C-reactive protein levels predict systolic heart failure and outcome in patients with first ST-elevation myocardial infarction treated with coronary angioplasty.Archives of medical science : AMS · 2017Article
- Clinical implications of plasma Nogo-A levels in patients with coronary heart disease.Archives of medical science : AMS · 2017Article
- Increased high-sensitivity C-reactive protein, erythrocyte sedimentation rate and lactic acid in stroke patients with internal carotid artery occlusion.Archives of medical science : AMS · 2016Article
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8 authors.
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Abstract
introductionThe relationship between plaque morphology detected by optical coherence tomography (OCT) and inflammatory biomarkers is not well known. MATERIAL AND
methodsThis study included 47 patients with ischemic heart disease (22 patients with acute coronary syndrome and 25 patients with effort angina pectoris) who underwent percutaneous coronary intervention (PCI). Before PCI, peripheral blood levels of the inflammatory biomarkers high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were measured. The OCT can detect thin-cap fibroatheroma (TCFA), a lesion with high potential for adverse cardiac events. We investigated the relationships between TCFAs in culprit lesions detected by OCT and the peripheral blood levels of these biomarkers.
resultsWe observed 12 lesions detected as TCFAs. The natural logs of hs-CRP and IL-6 levels in the TCFA group were higher than those in the non-TCFA group (hs-CRP 0.87 (-0.96 to 0.87) vs. -0.47 (-0.92 to 0.30) mg/l, p = 0.027; and IL-6 1.63 (0.63-3.23) vs. 0.53 (-0.21 to 1.05) pg/dl, p = 0.005, respectively). In multivariate logistic regression analysis, log IL-6 was an independent predictor for TCFA detected by OCT (log IL-6, 0.970 pg/dl, p = 0.023). Receiver operating characteristic curve analysis confirmed that IL-6, compared to hs-CRP, has a higher area under the curve for predicting TCFA (0.783 vs. 0.715, respectively).
conclusionsPeripheral blood levels of both hs-CRP and IL-6 were associated with TCFAs, as detected by OCT. Moreover, IL-6 has a higher potential than hs-CRP for predicting TCFA.
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