Evidence map›Paper›PMID 26170722›Full record

ReviewInternational journal of women's health2015

Endometriosis and ovarian cancer: links, risks, and challenges faced.

Mary Ellen Pavone, Brianna M Lyttle

Abstract readReview
In one paragraph

Review in International journal of women's health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Altered p16International journal of molecular sciences · 2022
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Endometriosis and risk of ovarian cancer: what do we know?Archives of gynecology and obstetrics · 2020
    Review
  16. Article
  17. Article
  18. Article
  19. Ovarian cancer in the world: epidemiology and risk factors.International journal of women's health · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mary Ellen PavoneDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Brianna M LyttleDepartment of Obstetrics and Gynecology, University of Massachusetts Medical School, Worcester, MA, USA.

Funding

Project 3: Medically-based Protection of the Ovarian Reserve Against Anti-CancerP50HD076188 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOODRUFF, TERESA K · 2014 to 2017
$6.2M
Ex Vivo Female Reproductive Tract Integration In a 3D Microphysiologic SystemUH3TR001207 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOODRUFF, TERESA K · 2014 to 2016
$4.9M
NCATS NIH HHS UH3 TR001207NICHD NIH HHS P50 HD076188
6 · The paper itself

Abstract

Endometriosis is a benign gynecological condition characterized by specific histological, molecular, and clinical findings. It affects 5%-10% of premenopausal women, is a cause of infertility, and has been implicated as a precursor for certain types of ovarian cancer. Advances in technology, primarily the ability for whole genome sequencing, have led to the discovery of new mutations and a better understanding of the function of previously identified genes and pathways associated with endometriosis associated ovarian cancers (EAOCs) that include PTEN, CTNNB1 (β-catenin), KRAS, microsatellite instability, ARID1A, and the unique role of inflammation in the development of EAOC. Clinically, EAOCs are associated with a younger age at diagnosis, lower stage and grade of tumor, and are more likely to occur in premenopausal women when compared with other ovarian cancers. A shift from screening strategies adopted to prevent EAOCs has resulted in new recommendations for clinical practice by national and international governing bodies. In this paper, we review the common histologic and molecular characteristics of endometriosis and ovarian cancer, risks associated with EAOCs, clinical challenges and give recommendations for providers.

Indexed as

clinicalinflammationmolecularpathwayspremenopausal

Identifiers

PMID26170722
PMCPMC4494101

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.