ReviewDiabetes, metabolic syndrome and obesity : targets and therapy2015
Epigenetic and developmental influences on the risk of obesity, diabetes, and metabolic syndrome.
Review in Diabetes, metabolic syndrome and obesity : targets and therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 1 synthesis or guideline pooled it, 177 citations in OpenAlex.
- Accelerated weight gain, prematurity, and the risk of childhood obesity: A meta-analysis and systematic review.PloS one · 2020Pooled it
- Effect of antenatal use of high energy nutritional supplements on cardio metabolic risk markers in underweight primi gravidas; a randomized controlled trial.BMC pregnancy and childbirth · 2024Trial
- Trial
- Epigenetic and immunological alterations in umbilical cord blood of overweight/obese women with gestational diabetes mellitus: insights into DNA methylation signatures and immune cell dysregulation.BMC pregnancy and childbirth · 2026Article
- Article
- Current Research on the Role of Isomaltooligosaccharides in Gastrointestinal Health and Metabolic Diseases.Preventive nutrition and food science · 2024Review
- Obesity in Pregnancy as a Risk Factor in Maternal and Child Health-A Retrospective Cohort Study.Metabolites · 2024Article
- A case-control regression analysis of liver enzymes in obesity-induced metabolic disorders in South Asian females.PloS one · 2024Article
- Benefits of Chronic Administration of a Carbohydrate-Free Diet on Biochemical and Morphometric Parameters in a Rat Model of Diet-Induced Metabolic Syndrome.Metabolites · 2023Article
- Placenta DNA methylation levels of the promoter region of the leptin receptor gene are associated with infant cortisol.Psychoneuroendocrinology · 2023Article
- Cardioprotective Effects of Dexmedetomidine in an Oxidative-Stress In Vitro Model of Neonatal Rat Cardiomyocytes.Antioxidants (Basel, Switzerland) · 2023Article
- Environmental Exposure: Effect on Maternal Morbidity and Mortality and Neonatal Health.Cureus · 2023Review
- Epigenetics of the Pathogenesis and Complications of Type 2 Diabetes Mellitus.TouchREVIEWS in endocrinology · 2023Review
- Phytocompounds targeting epigenetic modulations: an assessment in cancer.Frontiers in pharmacology · 2023Review
- Addressing Obesity in Preconception, Pregnancy, and Postpartum: A Review of the Literature.Current obesity reports · 2022Review
- Maternal Schizophrenia and the Risk of a Childhood Chronic Condition.Schizophrenia bulletin · 2022Article
- Article
- High visceral adipose tissue area is independently associated with early allograft dysfunction in liver transplantation recipients: a propensity score analysis.Insights into imaging · 2022Article
- Investigation ofMedicina (Kaunas, Lithuania) · 2022Article
- Maternal secretin ameliorates obesity by promoting white adipose tissue browning in offspring.EMBO reports · 2022Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic syndrome is a growing cause of morbidity and mortality worldwide. Metabolic syndrome is characterized by the presence of a variety of metabolic disturbances including obesity, hyperlipidemia, hypertension, and elevated fasting blood sugar. Although the risk for metabolic syndrome has largely been attributed to adult lifestyle factors such as poor nutrition, lack of exercise, and smoking, there is now strong evidence suggesting that predisposition to the development of metabolic syndrome begins in utero. First posited by Hales and Barker in 1992, the "thrifty phenotype" hypothesis proposes that susceptibility to adult chronic diseases can occur in response to exposures in the prenatal and perinatal periods. This hypothesis has been continually supported by epidemiologic studies and studies involving animal models. In this review, we describe the structural, metabolic and epigenetic changes that occur in response to adverse intrauterine environments including prenatal and postnatal diet, maternal obesity, and pregnancy complications. Given the increasing prevalence of metabolic syndrome in both the developed and developing worlds, a greater understanding and appreciation for the role of the intrauterine environment in adult chronic disease etiology is imperative.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.