ArticlePatient preference and adherence2015
Defining medication adherence in individual patients.
Article in Patient preference and adherence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Feasibility and Preliminary Outcomes of a Physical Therapist-Administered Physical Activity Intervention After Total Knee Replacement.Arthritis care & research · 2020Trial
- A Mixed Lipid Emulsion for Prevention of Parenteral Nutrition Associated Cholestasis in Extremely Low Birth Weight Infants: A Randomized Clinical Trial.The Journal of pediatrics · 2018Trial
- A novel statistical method for assessing effective adherence to medication and calculating optimal drug dosages.PloS one · 2018Trial
- The feasibility of a novel exercise therapy and activity modification intervention for patients with Sever's disease.Pilot and feasibility studies · 2026Article
- Validity and reliability of the Chinese beliefs about medicines questionnaire-specific in caregivers of children with Epilepsy.Frontiers in public health · 2025Article
- Prevalence and associated factors of non-adherence to antihyperlipidemic medication: a nationwide cross sectional survey in Pakistan.Scientific reports · 2024Article
- A Virtual Assistant to Guide Early Postoperative Rehabilitation after Reverse Shoulder Arthroplasty: A Pilot Randomized Trial.Bioengineering (Basel, Switzerland) · 2024Article
- Beliefs of patients who visited community pharmacies about medicines and supplements, the need for drug therapy and medication adherence - a cross-sectional study.Journal of pharmaceutical policy and practice · 2024Article
- Toward the Design of Sensing-Based Medication Adherence Aids That Support Individualized Activities of Daily Living: Survey and Interviews With Patients and Providers.JMIR human factors · 2023Article
- Effectiveness of using a chatbot to promote adherence to home physiotherapy after total knee replacement, rationale and design of a randomized clinical trial.BMC musculoskeletal disorders · 2023Article
- Association between illness perception and medication adherence in patients with diabetes mellitus in North Shoa, Zone: cross-sectional study.Frontiers in public health · 2023Article
- Medication Adherence and Compliance: Recipe for Improving Patient Outcomes.Pharmacy (Basel, Switzerland) · 2022Article
- First report of computational protein-ligand docking to evaluate susceptibility to HIV integrase inhibitors in HIV-infected Iranian patients.Biochemistry and biophysics reports · 2022Article
- Optimizing Therapeutic Outcomes With Oral Semaglutide: A Patient-Centered Approach.Diabetes spectrum : a publication of the American Diabetes Association · 2021Article
- Factors impacting on diabetes knowledge, medication adherence and glycemic control among adult diabetics visiting a county teaching and referral hospital in Kenya: a cross-sectional study.The Pan African medical journal · 2021Article
- Medication Adherence Interventions for Cardiovascular Disease in Low- and Middle-Income Countries: A Systematic Review.Patient preference and adherence · 2021Review
- Effect of Missed Doses on the Therapeutic Effect of Methotrexate for Rheumatoid Arthritis: A Pharmacokinetic Modeling Study.Open access rheumatology : research and reviews · 2021Article
- Exploring Medication Adherence Amongst Australian Adults Using an Extended Theory of Planned Behaviour.International journal of behavioral medicine · 2020Article
- Patterns of non-adherence to oral antiretroviral medication: frequencies of consecutively missed doses.Patient preference and adherence · 2019Article
- Is There a Threshold for Medication Adherence? Lessons Learnt From Electronic Monitoring of Drug Adherence.Frontiers in pharmacology · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe classification of patients as adherent or non-adherent to medications is typically based on an arbitrary threshold for the proportion of prescribed doses taken. Here, we define a patient as pharmacokinetically adherent if the serum drug levels resulting from his/her pattern of medication-taking behavior remained within the therapeutic range.
methodsWe used pharmacokinetic modeling to calculate serum drug levels in patients whose patterns of dosing were recorded by a medication event monitoring system. Medication event monitoring system data were from a previously published study of seven psoriasis patients prescribed 40 mg subcutaneous adalimumab at 14-day intervals for 1 year. Daily serum concentrations of adalimumab were calculated and compared with a known therapeutic threshold.
resultsNone of the seven patients took adalimumab precisely every 14 days. Three patients who took adalimumab at intervals of 6-26 days could be classified as pharmacokinetically adherent, because their daily adalimumab serum concentration never fell below the therapeutic threshold. The four other patients, who took adalimumab at intervals of 7-93 days, could be classified as pharmacokinetically non-adherent, because their adalimumab serum concentration fell below the therapeutic threshold on 3.5%-71.3% of days.
conclusionPatients with varying patterns of adalimumab dosing could be classified as pharmacokinetically adherent or non-adherent according to whether or not their serum drug concentrations remained within the therapeutic range.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.