Evidence map›Paper›PMID 26170530›Full record

Observational studyDisease markers2015

Serum Chemerin Levels in relation to Osteoporosis and Bone Mineral Density: A Case-Control Study.

Jing He, Ji-Chun Li, Hua Xie, Zhong-Hua Xu, Ya-Wen Sun, Qiao Shan

Abstract readObservational Study
In one paragraph

Observational study in Disease markers, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. The Innovative and Sustainable Use of Dental Panoramic Radiographs for the Detection of Osteoporosis.International journal of environmental research and public health · 2020
    Article
  7. Article
  8. Adipokines may mediate the relationship between resting metabolic rates and bone mineral densities in obese women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jing HeDepartment of Orthopedics, Jintan Hospital, Jiangsu University, Jintan 213200, China.
Ji-Chun LiDepartment of Orthopedics, Jintan Hospital, Jiangsu University, Jintan 213200, China.
Hua XieDepartment of Orthopedics, Jintan Hospital, Jiangsu University, Jintan 213200, China.
Zhong-Hua XuDepartment of Orthopedics, Jintan Hospital, Jiangsu University, Jintan 213200, China.
Ya-Wen SunDepartment of Orthopedics, Jintan Hospital, Jiangsu University, Jintan 213200, China.
Qiao ShanCollege of Medicine, Zhejiang University, Hangzhou 310058, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate serum chemerin levels in patients with osteoporosis and healthy controls and to investigate the relationship between serum chemerin levels and bone mineral density (BMD).

methodsAn age- and gender-matched case-control study was conducted. Pearson's correlation test was performed to investigate the relationship between serum chemerin levels and BMD.

resultsThere were 93 patients included in the osteoporosis group and 93 matched controls. Serum chemerin level was significantly higher in patients with osteoporosis (87.27 ± 5.80 ng/mL) than patients in control (71.13 ± 5.12 ng/mL) (P < 0.01). There was a negative correlation between femoral bone mineral density and chemerin in both groups (R = -0.395, P < 0.01 in osteoporosis group; R = -0.680, P < 0.01 in control) and also a negative correlation between lumbar bone mineral density with chemerin in both groups (R = -0.306, P < 0.01 in osteoporosis group; R = -0.362, P < 0.01 in control).

conclusionsPatients with osteoporosis presented a higher level of serum chemerin, which witnessed an inverse correlation with BMD. Further studies are needed to explore the role of chemerin in the pathophysiology of osteoporosis.

Indexed as

Bone DensityAgedCase-Control StudiesChemokinesFemaleFemurHumansIntercellular Signaling Peptides and ProteinsLumbar VertebraeMaleMiddle AgedOsteoporosisRadiographyChemokinesIntercellular Signaling Peptides and ProteinsRARRES2 protein, human

Identifiers

PMID26170530
PMCPMC4485501

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.