Evidence map›Paper›PMID 26170481›Full record

ReviewThe Ulster medical journal2015

Dementia.

E L Cunningham, B McGuinness, B Herron, A P Passmore

Open access · greenAbstract readReview
In one paragraph

Review in The Ulster medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 5 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 5 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Meta-Analysis on Nicotine's Modulation of HIV-Associated Dementia.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2022
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Present and Future of Ultra-High Field MRI in Neurodegenerative Disorders.Current neurology and neuroscience reports · 2018
    Pooled it
  6. Article
  7. Article
  8. Facial Expressions as a Nexus for Health Assessment.Bioengineering (Basel, Switzerland) · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. BMJ open · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Microglial Transforming Growth Factor-β Signaling in Alzheimer's Disease.International journal of molecular sciences · 2024
    Review
  19. Article
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

E L CunninghamCentre for Public Health, Queen's University Belfast.
B McGuinnessCentre for Public Health, Queen's University Belfast ; Belfast Health and Social Care Trust.
B HerronBelfast Health and Social Care Trust.
A P PassmoreCentre for Public Health, Queen's University Belfast ; Belfast Health and Social Care Trust.
Belfast Health and Social Care Trust · GBQueen's University Belfast · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dementia is a clinical diagnosis requiring new functional dependence on the basis of progressive cognitive decline. It is estimated that 1.3% of the entire UK population, or 7.1% of those aged 65 or over, have dementia. Applying these to 2013 population estimates gives an estimated number of 19,765 people living with dementia in Northern Ireland. The clinical syndrome of dementia can be due to a variety of underlying pathophysiological processes. The most common of these is Alzheimer's disease (50-75%) followed by vascular dementia (20%), dementia with Lewy bodies (5%) and frontotemporal lobar dementia (5%). The clinical symptoms and pathophysiological processes of these diseases overlap significantly. Biomarkers to aid diagnosis and prognosis are emerging. Acetylcholinesterase inhibitors and memantine are the only medications currently licensed for the treatment of dementia. The nature of symptoms mean people with dementia are more dependent and vulnerable, both socially and in terms of physical and mental health, presenting evolving challenges to society and to our healthcare systems.

Indexed as

BiomarkersCholinesterase InhibitorsDementiaHumansMemantineNeuroimagingNorthern IrelandPrevalenceReceptors, N-Methyl-D-AspartateBiomarkersCholinesterase InhibitorsMemantineReceptors, N-Methyl-D-Aspartate

Identifiers

PMID26170481
PMCPMC4488926
OpenAlexW4292580283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.