Evidence map›Paper›PMID 26170351›Full record

Trial reportBritish journal of anaesthesia2015

Pregabalin and pain after total knee arthroplasty: a double-blind, randomized, placebo-controlled, multidose trial.

J T YaDeau, Y Lin, D J Mayman, E A Goytizolo, M M Alexiades, D E Padgett, R L Kahn, K M Jules-Elysee, A S Ranawat, D D Bhagat and 4 more

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of anaesthesia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 6 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01333956 phase1 / phase2completednot on this map

Effects of Pregabalin on Pain After Total Knee Arthroplasty: A Randomized, Controlled, Double-Blind Trial

TypeinterventionalSponsorHospital for Special Surgery, New YorkRan2011 to 2013Enrolled120ConditionsPrimary Total Knee ArthroplastyArmsPregabalin 50mg, Pregabalin 100mg, Pregabalin 150mg, Placebo
NCT05447364 phase4completednot on this mapstarted 2021, after this paper: background citation

Efficacy of Different Doses of Pregabalin as a Multimodal Analgesic Agent in Postoperative Pain Control After Total Knee Arthroplasty - A Randomized Controlled Trial

TypeinterventionalSponsorThammasat UniversityRan2021 to 2024Enrolled82ConditionsKnee OsteoarthritisArmsPregabalin 75mg, Pregabalin 150mg
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 6 syntheses or guidelines pooled it, 90 citations in OpenAlex.

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  17. Opioid Prescription Consumption Patterns After Total Joint Arthroplasty in Chronic Opioid Users Versus Opioid Naive Patients.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2020
    Article
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  19. Regional and Multimodal Analgesia to Reduce Opioid Use After Total Joint Arthroplasty: A Narrative Review.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

J T YaDeauDepartment of Anesthesiology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA yadeauj@hss.edu.
Y LinDepartment of Anesthesiology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.
D J MaymanDeparment of Orthopaedic Surgery, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.
E A GoytizoloDepartment of Anesthesiology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.
M M AlexiadesDeparment of Orthopaedic Surgery, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.
D E PadgettDeparment of Orthopaedic Surgery, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.
R L KahnDepartment of Anesthesiology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.
K M Jules-ElyseeDepartment of Anesthesiology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.
A S RanawatDeparment of Orthopaedic Surgery, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.
D D BhagatDepartment of Anesthesiology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.
K G FieldsHealthcare Research Institute, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.
A K GoonDepartment of Anesthesiology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.
J CurrenDepartment of Anesthesiology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.
G H WestrichDeparment of Orthopaedic Surgery, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.
Hospital for Special Surgery · US

Funding

Clinical and Translational Science CenterUL1TR000457 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2012 to 2016
$46.0M
NCATS NIH HHS UL1 TR000457NCATS NIH HHS UL1 TR000457-06
6 · The paper itself

Abstract

backgroundPregabalin may reduce postoperative pain and opioid use. Higher doses may be more effective, but may cause sedation and confusion. This prospective, randomized, blinded, placebo-controlled study tested the hypothesis that pregabalin reduces pain at 2 weeks after total knee arthroplasty, but increases drowsiness and confusion.

methodsPatients (30 per group) received capsules containing pregabalin (0, 50, 100, or 150 mg); two capsules before surgery, one capsule twice a day until postoperative day (POD) 14, one on POD15, and one on POD16. Multimodal analgesia included femoral nerve block, epidural analgesia, oxycodone-paracetamol, and meloxicam. The primary outcome was pain with flexion (POD14).

resultsPregabalin did not reduce pain at rest, with ambulation, or with flexion at 2 weeks (P=0.69, 0.23, and 0.90, respectively). Pregabalin increased POD1 drowsiness (34.5, 37.9, 55.2, and 58.6% in the 0, 50, 100, and 150 mg arms, respectively; P=0.030), but did not increase confusion (0, 3.5, 0, and 3.5%, respectively; P=0.75). Pregabalin had no effect on acute or chronic pain, opioid consumption, or analgesic side-effects. Pregabalin reduced POD14 patient satisfaction [1-10 scale, median (first quartile, third quartile): 9 (8, 10), 8 (7, 10), 8 (5, 9), and 8 (6, 9.3), respectively; P=0.023). Protocol compliance was 63% by POD14 (50.0, 70.0, 76.7, and 56.7% compliance, respectively), with no effect of dose on compliance. Per-protocol analysis of compliant patients showed no effect of pregabalin on pain scores.

conclusionsPregabalin had no beneficial effects, but increased sedation and decreased patient satisfaction. This study does not support routine perioperative pregabalin for total knee arthroplasty patients. CLINICAL

trial registrationClinicalTrials.gov: http://www.clinicaltrials.gov/ct2/show/study/NCT01333956.

Indexed as

Arthroplasty, Replacement, KneeAdultAgedAnalgesicsDose-Response Relationship, DrugDouble-Blind MethodFemalegamma-Aminobutyric AcidHumansMaleMiddle AgedPostoperative PainPregabalinProspective StudiesAnalgesicsgamma-Aminobutyric AcidPregabalinanalgesiaanticonvulsantsarthroplastykneepain managementperioperative carereplacement

Identifiers

PMID26170351
PMCPMC4500762
OpenAlexW2307130724

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.