ArticleProceedings of the National Academy of Sciences of the United States of America2015
Signaling between periglomerular cells reveals a bimodal role for GABA in modulating glomerular microcircuitry in the olfactory bulb.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Generalization of fear learning is shaped by inhibitory sensory processing in mice.Nature communications · 2026Article
- Article
- Functional Maturation and Experience-Dependent Plasticity in Adult-Born Olfactory Bulb Dopaminergic Neurons.The European journal of neuroscience · 2025Article
- Pheromone Perception in Fish: Mechanisms and Modulation by Internal Status.Integrative and comparative biology · 2023Review
- Article
- Extrinsic neuromodulation in the rodent olfactory bulb.Cell and tissue research · 2021Review
- Short-term plasticity in glomerular inhibitory circuits shapes olfactory bulb output.Journal of neurophysiology · 2020Article
- Complex neural representation of odour information in the olfactory bulb.Acta physiologica (Oxford, England) · 2020Review
- Cortical Organization of Centrifugal Afferents to the Olfactory Bulb: Mono- and Trans-synaptic Tracing with Recombinant Neurotropic Viral Tracers.Neuroscience bulletin · 2019Article
- Basal forebrain GABAergic innervation of olfactory bulb periglomerular interneurons.The Journal of physiology · 2019Article
- A dominant role for the beta 4 nicotinic receptor subunit in nicotinic modulation of glomerular microcircuits in the mouse olfactory bulb.Journal of neurophysiology · 2018Article
- Embryonic and postnatal neurogenesis produce functionally distinct subclasses of dopaminergic neuron.eLife · 2018Article
- Adenosine AThe Journal of physiology · 2018Article
- The Physiological Foresight in Freeman's Work: Predictions and Verifications.Journal of consciousness studies : controversies in science & the humanities · 2018Article
- Inhibitory circuits of the mammalian main olfactory bulb.Journal of neurophysiology · 2017Review
- Olfactory Bulb Deep Short-Axon Cells Mediate Widespread Inhibition of Tufted Cell Apical Dendrites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Serotonin increases synaptic activity in olfactory bulb glomeruli.Journal of neurophysiology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In the mouse olfactory bulb glomerulus, the GABAergic periglomerular (PG) cells provide a major inhibitory drive within the microcircuit. Here we examine GABAergic synapses between these interneurons. At these synapses, GABA is depolarizing and exerts a bimodal control on excitability. In quiescent cells, activation of GABAA receptors can induce the cells to fire, thereby providing a means for amplification of GABA release in the glomerular microcircuit via GABA-induced GABA release. In contrast, GABA is inhibitory in neurons that are induced to fire tonically. PG-PG interactions are modulated by nicotinic acetylcholine receptors (nAChRs), and our data suggest that changes in intracellular calcium concentrations triggered by nAChR activation can be amplified by GABA release. Our results suggest that bidirectional control of inhibition in PG neurons can allow for modulatory inputs, like the cholinergic inputs from the basal forebrain, to determine threshold set points for filtering out weak olfactory inputs in the glomerular layer of the olfactory bulb via the activation of nAChRs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.