Evidence map›Paper›PMID 26170290›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2015

Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain.

Gerald J Sun, Yi Zhou, Ryan P Stadel, Jonathan Moss, Jing Hui A Yong, Shiori Ito, Nicholas K Kawasaki, Alexander T Phan, Justin H Oh, Nikhil Modak and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed.

  1. Review
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  8. Characterization of adult hippocampal neurogenesis in the novelbioRxiv : the preprint server for biology · 2025
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  12. Article
  13. Review
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  18. Neural Stem Cell-based Regenerative Therapy: A New Approach to Diabetes Treatment.Endocrine, metabolic & immune disorders drug targets · 2024
    Review
  19. Review
  20. Review

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Gerald J SunInstitute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
Yi ZhouInstitute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
Ryan P StadelInstitute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Predoctoral Human Genetics Training Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
Jonathan MossDepartment of Fundamental Neurosciences, University of Lausanne, 1005 Lausanne, Switzerland;
Jing Hui A YongCellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
Shiori ItoInstitute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
Nicholas K KawasakiInstitute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
Alexander T PhanInstitute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
Justin H OhInstitute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
Nikhil ModakInstitute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
Randall R ReedThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205;
Nicolas ToniDepartment of Fundamental Neurosciences, University of Lausanne, 1005 Lausanne, Switzerland;
Hongjun SongInstitute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Predoctoral Human Genetics Training Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205; shongju1@jhmi.edu gming1@jhmi.edu.
Guo-li MingInstitute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205 shongju1@jhmi.edu gming1@jhmi.edu.

Funding

Predoctoral Training Program in Human GeneticsT32GM007814 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 1985 to 2021
$10.6M
Development of new neurons in the adult brainR01NS047344 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SONG, HONGJUN · 2003 to 2011
$3.4M
Calcium signaling in neuronal navigationR01NS048271 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MING, GUO-LI · 2004 to 2014
$3.2M
Local circuitry mechanisms regulating adult hippocampal neurogenesisR37NS047344 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SONG, HONGJUN · 2013 to 2019
$2.9M
Circuitry mechanisms underlying normal and aberrant adult hippocampal neurogenesisR01MH105128 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MING, GUO-LI · 2014 to 2018
$2.0M
Circuitry mechanisms regulating adult hippocampal neurogenesisR56NS047344 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SONG, HONGJUN · 2012 to 2012
$405k
NIGMS NIH HHS T32 GM007814NIMH NIH HHS MH105128NIMH NIH HHS R01 MH105128NINDS NIH HHS NS047344NINDS NIH HHS NS048271NINDS NIH HHS R01 NS047344NINDS NIH HHS R01 NS048271NINDS NIH HHS R37 NS047344NINDS NIH HHS R56 NS047344
6 · The paper itself

Abstract

In a classic model of mammalian brain formation, precursors of principal glutamatergic neurons migrate radially along radial glia fibers whereas GABAergic interneuron precursors migrate tangentially. These migration modes have significant implications for brain function. Here we used clonal lineage tracing of active radial glia-like neural stem cells in the adult mouse dentate gyrus and made the surprising discovery that proliferating neuronal precursors of glutamatergic granule neurons exhibit significant tangential migration along blood vessels, followed by limited radial migration. Genetic birthdating and morphological and molecular analyses pinpointed the neuroblast stage as the main developmental window when tangential migration occurs. We also developed a partial "whole-mount" dentate gyrus preparation and observed a dense plexus of capillaries, with which only neuroblasts, among the entire population of progenitors, are directly associated. Together, these results provide insight into neuronal migration in the adult mammalian nervous system.

Indexed as

AnimalsBrainBrain MappingCell MovementDentate GyrusFemaleGlutamineGreen Fluorescent ProteinsHippocampusImaging, Three-DimensionalMiceMice, Inbred C57BLMice, TransgenicMicroscopy, ConfocalMicroscopy, FluorescenceModels, NeurologicalGlutamineGreen Fluorescent Proteinsadult neurogenesishippocampuslineage tracingmigrationvascular niche

Identifiers

PMID26170290
PMCPMC4522763

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.