Evidence map›Paper›PMID 26170234›Full record

ReviewNucleic acids research2015

The microRNA-183 cluster: the family that plays together stays together.

Shweta Dambal, Mit Shah, Brittany Mihelich, Larisa Nonn

Open access · goldAbstract readReview
In one paragraph

Review in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 219 citations in OpenAlex.

  1. NiClJournal of fluorescence · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. In search of epigenetic hallmarks of different tissues: an integrative omics study of horse liver, lung, and heart.Mammalian genome : official journal of the International Mammalian Genome Society · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shweta DambalDepartment of Pathology, University of Illinois at Chicago, 840 S. Wood Street, Room 130 CSN, MC 847, Chicago, IL 60612, USA.
Mit ShahDepartment of Pathology, University of Illinois at Chicago, 840 S. Wood Street, Room 130 CSN, MC 847, Chicago, IL 60612, USA.
Brittany MihelichDepartment of Pathology, University of Illinois at Chicago, 840 S. Wood Street, Room 130 CSN, MC 847, Chicago, IL 60612, USA.
Larisa NonnDepartment of Pathology, University of Illinois at Chicago, 840 S. Wood Street, Room 130 CSN, MC 847, Chicago, IL 60612, USA University of Illinois Cancer Center, Chicago, IL 60612, USA lnonn@uic.edu.
University of Illinois Chicago · US

Funding

MiR-183-96-182 cluster, prostatic zinc homeostasis and carcinogenesisR01CA166588 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI NONN, LARISA · 2012 to 2016
$1.9M
NCI NIH HHS CA R01 CA166588NCI NIH HHS R01 CA166588
6 · The paper itself

Abstract

The microRNA (miR)183 cluster, which is comprised of miRs-183, -96 and -182, is also a miR family with sequence homology. Despite the strong similarity in the sequences of these miRs, minute differences in their seed sequences result in both overlapping and distinct messenger RNA targets, which are often within the same pathway. These miRs have tightly synchronized expression during development and are required for maturation of sensory organs. In comparison to their defined role in normal development, the miR-183 family is frequently highly expressed in a variety of non-sensory diseases, including cancer, neurological and auto-immune disorders. Here, we discuss the conservation of the miR-183 cluster and the functional role of this miR family in normal development and diseases. We also describe the regulation of vital cellular pathways by coordinated expression of these miR siblings. This comprehensive review sheds light on the likely reasons why the genomic organization and seeming redundancy of the miR-183 family cluster was conserved through 600 million years of evolution.

Indexed as

Multigene FamilyAnimalsDiseaseGene Expression RegulationGrowth and DevelopmentHumansMicroRNAsMicroRNAsMirn182 microRNA, humanMIRN183 microRNA, humanMIRN96 microRNA, human

Identifiers

PMID26170234
PMCPMC4551935
OpenAlexW1916543860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.