Evidence map›Paper›PMID 26170158›Full record

Trial reportWorld journal of surgery2015

A Multi-institutional, Prospective, Phase II Feasibility Study of Laparoscopy-Assisted Distal Gastrectomy with D2 Lymph Node Dissection for Locally Advanced Gastric Cancer (JLSSG0901).

Noriyuki Inaki, Tsuyoshi Etoh, Tetsuji Ohyama, Kazuhisa Uchiyama, Natsuya Katada, Keisuke Koeda, Kazuhiro Yoshida, Akinori Takagane, Kazuyuki Kojima, Shinichi Sakuramoto and 2 more

2 registry-linked trialsAbstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in World journal of surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 184 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
184citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03007550 nacompletednot on this mapstarted 2017, after this paper: background citation

Prospective Randomized Controlled Multicenter Clinical Trial For Comparison Of Safety Between Laparoscopic And Open Total Gastrectomy In Patients With Clinical Stage I Gastric Cancer

TypeinterventionalSponsorShanghai Zhongshan HospitalRan2017 to 2018Enrolled227ConditionsGastric CancerArmsLaparoscopic total gastrectomy, Open total gastrectomy
NCT03273920 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Robotic Versus Laparoscopic Distal Gastrectomy With D2 Lymphadenectomy for Locally Advanced Gastric Cancer: a Multicenter Randomized Controlled Trial

TypeinterventionalSponsorSouthwest Hospital, ChinaRan2017 to 2022Enrolled1,110ConditionsGastric CancerArmsRobotic distal gastrectomy with D2 nodal dissection, Laparoscopic distal gastrectomy with D2 nodal dissection
3 · Its place in the literature

Who cites it

184 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Japanese gastric cancer treatment guidelines 2025 (7th edition).Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
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  5. [Evidence in minimally invasive oncological gastric surgery].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021
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  11. Short-term outcomes of preoperative computed tomography angiography versus standard assessment in patients with BMI ≥ 25.0 kg/mGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025
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  17. A feasibility study of laparoscopic total gastrectomy for clinical stage I gastric cancer: a prospective multi-center phase II clinical trial, KLASS 03.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2019
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  20. Protocol for enhanced recovery after surgery improves short-term outcomes for patients with gastric cancer: a randomized clinical trial.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2017
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124 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Noriyuki InakiDepartment of Gastroenterological Surgery, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.
Tsuyoshi EtohDepartment of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Hasama-machi, Oita, 879-5593, Japan. teto@oita-u.ac.jp.
Tetsuji OhyamaDepartment of Mathematics and Statistics, Oita University Faculty of Medicine, Oita, Japan.
Kazuhisa UchiyamaDepartment of General and Gastroenterological Surgery, Osaka Medical College, Takatsuki, Japan.
Natsuya KatadaDepartment of Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
Keisuke KoedaDepartment of Surgery, Iwate Medical University School of Medicine, Morioka, Japan.
Kazuhiro YoshidaDepartment of Surgical Oncology, Gifu University, Gifu, Japan.
Akinori TakaganeDepartment of Surgery, Hakodate Goryoukaku Hospital, Hakodate, Japan.
Kazuyuki KojimaCenter for Minimally Invasive Surgery, Tokyo Medical and Dental University, Bunkyō, Japan.
Shinichi SakuramotoDepartment of Gastroenterological Surgery, Comprehensive Cancer Center, Saitama International Medical Center, Saitama Medical University, Saitama, Japan.
Norio ShiraishiCenter for Community Medicine, Oita University Faculty of Medicine, Oita, Japan.
Seigo KitanoOita University, Oita, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe efficacy and safety outcomes of laparoscopy-assisted distal gastrectomy (LADG) with D2 lymph node dissection for locally advanced gastric cancer remain unclear. Therefore, we conducted a randomized, controlled phase II trial to confirm the feasibility of LADG in terms of technical safety, and short-term surgical outcomes were investigated.

methodsEligibility criteria included pre-operatively diagnosed advanced gastric cancer that could be treated by distal gastrectomy with D2 lymph node dissection; MP, SS, and SE without involvement of other organs; and N0-2 and M0. Patients aged 20-80 years were pre-operatively randomized.

resultsIn total, 180 patients were registered and randomized to the open (89 patients) and laparoscopic arms (91 patients). Among 91 patients in the laparoscopic arm, 86 underwent laparoscopic gastrectomy according to the study protocol. Regarding the primary endpoint of the phase II trial, the proportion of patients with either anastomotic leakage or pancreatic fistula was 4.7 % (4/86). The grade 3 or higher morbidity rate, including systemic and local complications, was 5.8 %. Conversion to open surgery was required for 1 patient (1.2 %), without any intra-operative complication. The post-operative mortality rate was 0, and no patient required readmission for surgical complications within 6 months after initial discharge.

conclusionsThe technical safety of LADG with D2 lymph node dissection for locally advanced gastric cancer was demonstrated. A phase III trial to confirm the non-inferiority of this procedure to open gastrectomy in terms of long-term outcomes is ongoing. Registered Number: UMIN 000003420 ( www.umin.ac.jp/ctr/).

Indexed as

AdultAgedAged, 80 and overAnastomotic LeakConversion to Open SurgeryFeasibility StudiesFemaleGastrectomyGastroenterostomyHumansIntraoperative ComplicationsLaparoscopyLymphatic MetastasisLymph Node ExcisionMaleMiddle Aged

Identifiers

PMID26170158

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.