Evidence map›Paper›PMID 26170157›Full record

SynthesisWorld journal of surgery2015

Local Application of Gentamicin in the Prophylaxis of Perineal Wound Infection After Abdominoperineal Resection: A Systematic Review.

G D Musters, J W A Burger, C J Buskens, W A Bemelman, P J Tanis

Registry-linked trialOpen access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in World journal of surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03574090 (PROTOP), which is not on this map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03574090 phase4completednot on this mapstarted 2020, after this paper: background citation

PROTOP: Study of the Efficacy of Topical Antibiotherapy in the Prophylaxis of Incisional Surgical Localization Infection in Colorectal Surgery

TypeinterventionalSponsorUniversitat Internacional de CatalunyaRan2020 to 2023Enrolled268ConditionsSurgical Wound Infection, Postoperative Wound Infection, Postoperative Wound Infection Superficial Incisional, Preventive TherapyArmsAmoxicillin Clavulanate, Physiological Saline
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Management of Perineal Wounds Following Pelvic Surgery.Clinics in colon and rectal surgery · 2022
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

G D MustersDepartment of Surgery, Academic Medical Center, University of Amsterdam, Post box 22660, 1105 AZ, Amsterdam, The Netherlands. G.D.Musters@amc.uva.nl.
J W A BurgerDepartment of Surgery, Erasmus Medical Center/Daniel den Hoed, Post box 5201, 3008 AE, Rotterdam, The Netherlands. J.Burger@erasmusmc.nl.
C J BuskensDepartment of Surgery, Academic Medical Center, University of Amsterdam, Post box 22660, 1105 AZ, Amsterdam, The Netherlands. C.J.Buskens@amc.uva.nl.
W A BemelmanDepartment of Surgery, Academic Medical Center, University of Amsterdam, Post box 22660, 1105 AZ, Amsterdam, The Netherlands. W.A.Bemelman@amc.uva.nl.
P J TanisDepartment of Surgery, Academic Medical Center, University of Amsterdam, Post box 22660, 1105 AZ, Amsterdam, The Netherlands. P.J.Tanis@amc.nl.
University of Amsterdam · NLAcademic Medical Center · NLErasmus University Rotterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUse of topical antibiotics to improve perineal wound healing after abdominoperineal resection (APR) is controversial. The aim of this systematic review was to determine the impact of local application of gentamicin on perineal wound healing after APR.

methodsThe electronic databases Pubmed, EMBASE, and Cochrane library were searched in January 2015. Perineal wound outcome was categorized as infectious complications, non-infectious complications, and primary perineal wound healing.

resultsFrom a total of 582 articles, eight studies published between 1988 and 2012 were included: four randomized controlled trials (RCTs), three comparative cohort studies, and one cohort study without control group. Gentamicin was administered using sponges (n = 3), beads (n = 4), and by local injection (n = 1). There was substantial heterogeneity regarding underlying disease, definition of outcome parameters and timing of perineal wound evaluation among the included studies, which precluded meta-analysis with pooling. Regarding infectious complications, three of six evaluable studies demonstrated a positive effect of local application of gentamicin: one of four RCTs and both comparative cohort studies. Only two RCTs reported on non-infectious complications, showing no significant impact of gentamicin sponge. All three comparative cohort studies demonstrated a significantly higher percentage of primary perineal wound healing after local application of gentamicin beads, but only one out of three evaluable RCTs did show a positive effect of gentamicin sponges.

conclusionCurrently available evidence does not support perineal gentamicin application after APR.

Indexed as

AbdomenAnti-Bacterial AgentsAntibiotic ProphylaxisGentamicinsHumansPerineumRectal NeoplasmsSurgical Wound InfectionWound HealingAnti-Bacterial AgentsGentamicins

Identifiers

PMID26170157
PMCPMC4591195
OpenAlexW1773979225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.