Evidence map›Paper›PMID 26170147›Full record

ReviewHistochemistry and cell biology2015

Chromatin at the nuclear periphery and the regulation of genome functions.

Charlene Lemaître, Wendy A Bickmore

Abstract readReview
PubMed Publisher
In one paragraph

Review in Histochemistry and cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Tracing the Chromatin: From 3C to Live-Cell Imaging.Chemical & biomedical imaging · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Phase Separation and Correlated Motions in Motorized Genome.The journal of physical chemistry. B · 2022
    Article
  10. Article
  11. A systematic analysis ofGenome research · 2021
    Article
  12. The 3D Genome: From Structure to Function.International journal of molecular sciences · 2021
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Organization of fast and slow chromatin revealed by single-nucleosome dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Charlene LemaîtreMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XU, UK, charlene.lemaitre@igmm.ed.ac.uk.
Wendy A Bickmore
Institute of Genetics and Cancer · GB

Funding

Medical Research Council 249956Medical Research Council MC_PC_U127527202
6 · The paper itself

Abstract

Chromatin is not randomly organized in the nucleus, and its spatial organization participates in the regulation of genome functions. However, this spatial organization is also not entirely fixed and modifications of chromatin architecture are implicated in physiological processes such as differentiation or senescence. One of the most striking features of chromatin architecture is the concentration of heterochromatin at the nuclear periphery. A closer examination of the association of chromatin at the nuclear periphery reveals that heterochromatin accumulates at the nuclear lamina, whereas nuclear pores are usually devoid of heterochromatin. After summarizing the current techniques used to study the attachment of chromatin at the nuclear lamina or the nuclear pores, we review the mechanisms underlying these attachments, their plasticity and their consequences on the regulation of gene expression, DNA repair and replication.

Indexed as

AnimalsCell NucleusChromatinGenomeHumansNuclear LaminaNuclear PoreChromatin

Identifiers

PMID26170147
OpenAlexW1924323830

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.