ArticleHistochemistry and cell biology2015
The role of APCDD1 in epithelial rearrangement in tooth morphogenesis.
Article in Histochemistry and cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Developmental roles of glomerular epithelial protein-1 in mice molar morphogenesis.Cell and tissue research · 2024Article
- Developmental function of Piezo1 in mouse submandibular gland morphogenesis.Histochemistry and cell biology · 2023Article
- Signaling Modulations of miR-206-3p in Tooth Morphogenesis.International journal of molecular sciences · 2020Article
- Immunolocalization patterns of cytokeratins during salivary acinar cell development in mice.Journal of molecular histology · 2018Article
- Regulation of mesenchymal signaling in palatal mucosa differentiation.Histochemistry and cell biology · 2018Article
- A novel mutation of adenomatous polyposis coli (APC) gene results in the formation of supernumerary teeth.Journal of cellular and molecular medicine · 2018Article
- The continuing problem of poor transparency of reporting and use of inappropriate methods for RT-qPCR.Biomolecular detection and quantification · 2017Article
- A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.The Journal of biological chemistry · 2017Article
- Grhl3 modulates epithelial structure formation of the circumvallate papilla during mouse development.Histochemistry and cell biology · 2017Article
- The Histochemistry and Cell Biology omnium-gatherum: the year 2015 in review.Histochemistry and cell biology · 2016Review
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adenomatosis polyposis coli downregulated 1 (APCDD1), a negative regulator of Wnt signaling, was examined to understand detailed mechanisms underlying Wnt signaling tooth development. In situ hybridization showed that Apcdd1 was expressed in the condensed mesenchyme at the bud stage, and in the inner enamel epithelium (IEE), including enamel knot (EK) at the cap stage. In vitro organ cultivation by using Apcdd1 antisense oligodeoxynucleotides was performed at E13.5 for 2 days to define the developmental functions of APCDD1 during tooth development. Analysis of histogenesis and cellular events such as cell adhesion, proliferation, apoptosis and epithelial rearrangement after Apcdd1 knockdown showed altered morphogenesis of the tooth germ with decreased cell proliferation and altered localization of cell adhesion molecules. Actin filament staining and 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI) labeling of IEE cells showed that Apcdd1 knockdown enhanced epithelial rearrangement in the IEE and EK. To understand the precise signaling regulations of Apcdd1, we evaluated the altered expression patterns of signaling molecules, related with Wnt and enamel knot signalings using RT-qPCR. Tooth germs at cap stage were transplanted into the kidney capsules and were allowed to develop into calcified teeth for 3 weeks. Apcdd1 knockdown increased the number of ectopic cusps on the mesial side of the tooth. Our results suggested that APCDD1 modulates the gene expression of Wnt- and EK-related signaling molecules at the cap stage of tooth development, and is involved in tooth cusp patterning by modulating the epithelial rearrangement in the IEE.
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Registered trials
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