Evidence map›Paper›PMID 26170006›Full record

ArticleDevelopmental and comparative immunology2015

Retention of duplicated ITAM-containing transmembrane signaling subunits in the tetraploid amphibian species Xenopus laevis.

S V Guselnikov, L Grayfer, F De Jesús Andino, I B Rogozin, J Robert, A V Taranin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental and comparative immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

S V GuselnikovInstitute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Avenue 8/2, Novosibirsk 630090, Russia; Novosibirsk State University, Pirogov Street 2, Novosibirsk 630090, Russia. Electronic address: sguselnikov@mcb.nsc.ru.
L GrayferUniversity of Rochester, Medical Center, 601 Elmwood Avenue, MRBX, Rochester, NY 14642, USA. Electronic address: Leon_Grayfer@urmc.rochester.edu.
F De Jesús AndinoUniversity of Rochester, Medical Center, 601 Elmwood Avenue, MRBX, Rochester, NY 14642, USA. Electronic address: f_dejesus7@yahoo.com.
I B RogozinNational Center for Biotechnology Information NLM, National Institutes of Health, 8600 Rockville Pike, Bldg. 38A, Bethesda, MD, USA. Electronic address: rogozin@ncbi.nlm.nih.gov.
J RobertUniversity of Rochester, Medical Center, 601 Elmwood Avenue, MRBX, Rochester, NY 14642, USA. Electronic address: Jacques_Robert@urmc.rochester.edu.
A V TaraninInstitute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Avenue 8/2, Novosibirsk 630090, Russia; Novosibirsk State University, Pirogov Street 2, Novosibirsk 630090, Russia. Electronic address: taranin@mcb.nsc.ru.
University of Rochester Medical Center · USNovosibirsk State University · RUNational Institutes of Health · US

Funding

A Xenopus Laevis Research Resource for ImmunologyR24AI059830 · NIAID · UNIVERSITY OF ROCHESTER · PI JACQUES Robert · 2004 to 2026
$7.7M
Intramural NIH HHS Z99 LM999999NIAID NIH HHS R24 AI059830NIAID NIH HHS R24-AI-059830
6 · The paper itself

Abstract

The ITAM-bearing transmembrane signaling subunits (TSS) are indispensable components of activating leukocyte receptor complexes. The TSS-encoding genes map to paralogous chromosomal regions, which are thought to arise from ancient genome tetraploidization(s). To assess a possible role of tetraploidization in the TSS evolution, we studied TSS and other functionally linked genes in the amphibian species Xenopus laevis whose genome was duplicated about 40 MYR ago. We found that X. laevis has retained a duplicated set of sixteen TSS genes, all except one being transcribed. Furthermore, duplicated TCRα loci and genes encoding TSS-coupling protein kinases have also been retained. No clear evidence for functional divergence of the TSS paralogs was obtained from gene expression and sequence analyses. We suggest that the main factor of maintenance of duplicated TSS genes in X. laevis was a protein dosage effect and that this effect might have facilitated the TSS set expansion in early vertebrates.

Indexed as

TetraploidyAmino Acid SequenceAnimalsBase SequenceCell LineEvolution, MolecularHEK293 CellsHumansImmunoreceptor Tyrosine-Based Activation MotifMolecular Sequence DataReceptors, Antigen, T-Cell, alpha-betaReceptors, IgGSequence AlignmentSignal TransductionXenopus laevisReceptors, Antigen, T-Cell, alpha-betaReceptors, IgGActivating receptor complexesGenome miningImmunogeneticsProtein dosage effectTCRTetraploidizationXenopus

Identifiers

PMID26170006
PMCPMC4536121
OpenAlexW888568995

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.