ArticleSocial psychiatry and psychiatric epidemiology2015
The role of allelic variation in estrogen receptor genes and major depression in the Nurses Health Study.
Article in Social psychiatry and psychiatric epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 27 citations in OpenAlex.
- The relationship between vitamin D levels and depression: a genetically informed study.Nutrition journal · 2025Article
- Sex-Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome-Wide Association Study of All of Us and UK Biobank Data.Genetic epidemiology · 2025Article
- Androgen regulation of behavioral stress responses and the hypothalamic-pituitary-adrenal axis.Hormones and behavior · 2024Review
- Polymorphism of Estrogen Receptor Genes and Its Interactions With Neurodevelopmental Genes in Attention Deficit Hyperactivity Disorder Among Chinese Han Descent.Psychiatry investigation · 2023Article
- Functional Genomics Analysis to Disentangle the Role of Genetic Variants in Major Depression.Genes · 2022Article
- Androgens and Their Role in Regulating Sex Differences in the Hypothalamic/Pituitary/Adrenal Axis Stress Response and Stress-Related Behaviors.Androgens: clinical research and therapeutics · 2021Review
- Roles for androgens in mediating the sex differences of neuroendocrine and behavioral stress responses.Biology of sex differences · 2020Review
- Genetic Intersections of Language and Neuropsychiatric Conditions.Current psychiatry reports · 2020Review
- Expression ofPrzeglad menopauzalny = Menopause review · 2019Article
- Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females.Brain sciences · 2018Article
- Investigation of variants in estrogen receptor genes and perinatal depression.Neuropsychiatric disease and treatment · 2018Article
- Increased Serum G Protein-coupled Estrogen Receptor 1 Levels and Its Diagnostic Value in Drug Naïve Patients with Major Depressive Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2017Article
- Polymorphisms in sex steroid receptors: From gene sequence to behavior.Frontiers in neuroendocrinology · 2017Review
- Article
- Sex-specific hippocampal 5-hydroxymethylcytosine is disrupted in response to acute stress.Neurobiology of disease · 2016Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
purposeThe role of exogenous and endogenous sex hormones in the etiology of depression remains elusive, in part because sex hormone variation is often correlated with behaviors, life stage changes, and other factors that may influence depression. Estrogen receptor alpha (ESR1) and beta (ESR2) are known to regulate gene expression and estrogen response in areas of the brain associated with major depression and are unlikely to be correlated with exogenous factors that may influence depression.
methodsWe examined whether functional polymorphisms in these genes are associated with lifetime major depression and chronic major depression among a sample of women from the Nurses' Health Study II (N = 2527). DSM-IV depressive disorder symptoms were assessed by structured interview in 2007. Genotyping was performed on DNA extracted from blood using Taq-man.
resultsWomen with the AA alleles of ESR2 RS4986938 had the higher prevalence of lifetime major depression than women with other allele frequencies (36.7 % for those with AA versus 28.5 % with GA and 29.1 % with GG, p = 0.02) and chronic major depression (14.7 % for those with AA versus 9.3 % with GA and 9.1 % with GG, p = 0.01). History of post-menopausal hormone (PMH) use modified the association of ESR1 polymorphism RS2234693 with any lifetime depression; specifically, those with the TT allele had the highest risk of lifetime depression among PMH users, and the lowest risk of depression among non-PMH users (p value for interaction = 0.02). Further, carriers of the AA alleles in ESR1 polymorphism RS9340799 had increased prevalence of lifetime major depression only among lifetime PMH users (p = 0.007).
conclusionsOur findings support the hypothesis that estrogen receptor polymorphisms influence risk for major depression; the role of estrogen receptors and other sex steroid-related genetic factors may provide unique insights into etiology.
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