ArticleMolecular psychiatry2016
Biophysical changes in subcortical nuclei: the impact of diabetes and major depression.
Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- High-field magnetic resonance imaging of structural alterations in first-episode, drug-naive patients with major depressive disorder.Translational psychiatry · 2016Article
- Cognitive and connectome properties detectable through individual differences in graphomotor organization.Neuropsychologia · 2016Article
- Cognitive decline and neuroimaging correlates in comorbid type 2 diabetes and depression: A systematic review.Journal of Alzheimer's disease reportsReview
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7 authors.
Funding
Abstract
Magnetization transfer (MT) is a neuroimaging technique that is frequently used to characterize the biophysical abnormalities in both gray and white matter regions of the brain. In our study, we used MT to examine the integrity of key nodes in frontal-subcortical circuits in four subject groups: patients diagnosed with type 2 diabetes with and without major depression (MDD), a healthy control group, and a group diagnosed with MDD without diabetes. In the MDD group, MT studies demonstrated lower magnetization transfer ratios (MTR), a marker of abnormalities in the macromolecular protein pool, in the thalami when compared with the control groups. The group with diabetes and MDD showed lower MTR in the globus pallidus when compared with the group with MDD. Biophysical measures, in subcortical nuclei, correlated inversely with measures of glycemic control, cerebrovascular burden and depression scores. These findings have broad implications for the underlying neuronal circuitry and neurobiology of mood disorders.
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