ReviewSleep & breathing = Schlaf & Atmung2016
Obstructive sleep apnea syndrome: coagulation anomalies and treatment with continuous positive airway pressure.
Review in Sleep & breathing = Schlaf & Atmung, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- The role of obstructive sleep apnea on the prognosis of pulmonary embolism: a systemic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2021Pooled it
- Association between sleep-disordered breathing and lower extremity artery disease: a meta-analysis.Sleep & breathing = Schlaf & Atmung · 2021Pooled it
- Effects of continuous positive airway pressure on plasma fibrinogen levels in obstructive sleep apnea patients: a systemic review and meta-analysis.Bioscience reports · 2021Pooled it
- Article
- The relationship between clinical severity of obstructive sleep apnea based on polysomnography and drug-induced sleep endoscopy with 3D, 2D, linear, and angular anatomical parameters of upper airway and craniofacial area in CBCTs of individuals with moderate or severe apnea: a cross-sectional study.Clinical oral investigations · 2026Article
- The Association Between Obesity, Obstructive Sleep Apnea, and Postoperative Complications in Breast Reduction Patients: A Propensity Score-Matched Analysis.Aesthetic surgery journal. Open forum · 2026Article
- Sleep disorders in the acute phase of coronavirus disease 2019: an overview and risk factor study.Annals of general psychiatry · 2023Article
- Obstructive Sleep Apnea as a Risk Factor for Venous Thromboembolism: A Systematic Review.Cureus · 2022Review
- Sex-differences in the effect of obstructive sleep apnea on patients hospitalized with pulmonary embolism and on in-hospital mortality.Scientific reports · 2021Article
- The Neuropsychological Profile of Attention Deficits of Patients with Obstructive Sleep Apnea: An Update on the Daytime Attentional Impairment.Brain sciences · 2020Article
- Impact of Obstructive Sleep Apnea on Platelet Function Profiles in Patients With Acute Coronary Syndrome Taking Dual Antiplatelet Therapy.Journal of the American Heart Association · 2018Observational
- Is acute pulmonary embolism more severe in the presence of obstructive sleep apnea? Results from an observational cohort study.Journal of thrombosis and thrombolysis · 2018Observational
- Obstructive Sleep Apnea With or Without Excessive Daytime Sleepiness: Clinical and Experimental Data-Driven Phenotyping.Frontiers in neurology · 2018Article
- Association between obstructive sleep apnea severity and endothelial dysfunction in patients with type 2 diabetes.Cardiovascular diabetology · 2017Article
- Obstructive sleep apnea might trigger acute pulmonary embolism: results from a cohort study.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionObstructive sleep apnea syndrome (OSAS) is a highly prevalent sleep disorder associated with severe cardiovascular events, morbidity and mortality. Recent evidence has highlighted OSAS as an independent risk factor for an excessive platelet activation and arterial thrombosis, but the underlying mechanisms have not yet been determined. Studies in cell culture and animal models have significantly increased our understanding of the mechanisms of inflammation in OSAS. Hypoxia is a critical pathophysiological element that leads to an intense sympathetic activity, in association with systemic inflammation, oxidative stress and procoagulant activity. While platelet dysfunction and/or hypercoagulability play an important role in the pathogenesis of vascular disease, there are limited studies on the potential role of blood viscosity in the development of vascular disease in OSAS.
conclusionFurther studies are required to determine the precise role of hypercoagulability in the cardiovascular pathogenesis of OSAS, particularly its interaction with oxidative stress, thrombotic tendency and endothelial dysfunction. Nasal continuous positive airway pressure (nCPAP), the gold standard treatment for OSAS, not only significantly reduced apnea-hypopnoea indices but also markers of hypercoagulability, thus representing a potential mechanisms by which CPAP reduces the rate of cardiovascular morbidity and mortality in OSAS patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.