Evidence map›Paper›PMID 26169607›Full record

ArticleCell research2015

Expanding intestinal stem cells in culture.

Inha Heo, Hans Clevers

Abstract readComment
In one paragraph

Article in Cell research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. TGFβ-Directed Therapeutics: 2020.Pharmacology & therapeutics · 2021
    Review
  3. Article
  4. Review
  5. Chemoprevention of hereditary colon cancers: time for new strategies.Nature reviews. Gastroenterology & hepatology · 2016
    Review
  6. Mechanisms of intestinal adaptation.Best practice & research. Clinical gastroenterology · 2016
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Inha HeoHubrecht Institute, Royal Academy of Arts and Science (KNAW) and University Medical Centre Utrecht, Uppsalalaan 8, 3584CT, Utrecht, The Netherlands.
Hans CleversHubrecht Institute, Royal Academy of Arts and Science (KNAW) and University Medical Centre Utrecht, Uppsalalaan 8, 3584CT, Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Culturing intestinal stem cells into 3D organoids results in heterogeneous cell populations, reflecting the in vivo cell type diversity. In a recent paper published in Nature, Wang et al. established a culture condition for a highly homogeneous population of intestinal stem cells.

Indexed as

HumansIntestinesStem Cells

Identifiers

PMID26169607
PMCPMC4559810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.