Evidence map›Paper›PMID 26169592›Full record

Trial reportTrials2015

Decision aid on radioactive iodine treatment for early stage papillary thyroid cancer: update to study protocol with follow-up extension.

Anna M Sawka, Sharon Straus, Gary Rodin, Kevin E Thorpe, Shereen Ezzat, Amiram Gafni, David P Goldstein

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01083550 phase2 / phase3completednot on this map

Decision Aid on Radioactive Iodine Treatment for Early Stage Papillary Thyroid Cancer (Randomized Controlled Trial)

TypeinterventionalSponsorUniversity Health Network, TorontoRan2010 to 2016Enrolled74ConditionsThyroid CancerArmsDecision aid exposure
NCT06980103 narecruitingnot on this mapstarted 2025, after this paper: background citation

Use of a Decision Aid to Resolve Uncertainty About Radioactive Iodine Treatment in Patients With Intermediate Risk Thyroid Cancer: The Radiance Trial

TypeinterventionalSponsorGeorgetown UniversityRan2025 to 2029Enrolled408ConditionsThyroid CancerArmsDecision Aid, Usual Care
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Disparities in Thyroid Care.Endocrinology and metabolism clinics of North America · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Anna M SawkaDivision of Endocrinology, Department of Medicine, University Health Network, 200 Elizabeth Street, 12 EN-212, Toronto, Ontario, Canada, M5G 2C4. sawkaam@yahoo.com.
Sharon StrausDepartment of Medicine, St Michael's Hospital and University of Toronto, 30 Bond Street, Shuter 2-026, Toronto, Ontario, Canada, M5B 1W8. sharon.straus@utoronto.ca.
Gary RodinDepartment of Psychosocial Oncology, University Health Network and University of Toronto, 16th Floor Room 724, 610 University Avenue, Toronto, Ontario, Canada, M5G 2M9. gary.rodin@uhn.ca.
Kevin E ThorpeKeenan Research Centre, Li Ka Shing Knowledge Institute of St Michael's Hospital and the Dalla Lana School of Public Health, University of Toronto, 250 Yonge St., 6th Floor, Toronto, Ontario, Canada, M5B 1M8. kevin.thorpe@utoronto.ca.
Shereen EzzatDivision of Endocrinology, Department of Medicine, University Health Network, 200 Elizabeth Street, 12 EN-212, Toronto, Ontario, Canada, M5G 2C4. shereen.ezzat@uhn.ca.
Amiram GafniDepartment of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, CRL-208, Hamilton, Ontario, Canada, L8S 4K1. gafni@mcmaster.ca.
David P GoldsteinDepartment of Otolaryngology Head and Neck Surgery, University Health Network and University of Toronto, Wharton Head and Neck Centre 3-952, 610 University Avenue, Toronto, Ontario, Canada, M5G 2M9. david.goldstein@uhn.ca.
University Health Network · CASt. Michael's Hospital · CAMcMaster University · CAUniversity of Toronto · CA

Funding

Canadian Institutes of Health Research CNI-80701Canadian Institutes of Health Research FRN 111416
6 · The paper itself

Abstract

backgroundPatient decision aids (P-DAs) are used to inform patients about healthcare choices, but there is limited knowledge about their longer term effects, beyond the time period of decision-making. METHODS/

designWe developed a computerized P-DA that explains the choice of radioactive iodine (RAI) adjuvant treatment or no RAI, for patients with low risk papillary thyroid cancer after total thyroidectomy. The original protocol for a randomized controlled trial, comparing the use of the P-DA (with usual care) to usual care alone, has been published in Trials http://www.trialsjournal.com/content/11/1/81. We found that P-DA (with usual care) significantly improved patients' medical knowledge at the time of decision-making (primary outcome) compared to usual care alone (control). In this update, we present the protocol for an extended follow-up study (15 to 23 months post-randomization), including qualitative and quantitative methods. The patient outcomes evaluated using quantitative questionnaires include: the degree to which patients feel well-informed about their RAI treatment choice, decision satisfaction, decision regret, cancer-related worry, mood, and trust in the treating physician. The qualitative component explores the experiences of RAI treatment decision-making, treatment satisfaction, and trial participation in a representative subgroup of patients. Extended follow-up study results will be described for the entire study population, and data will be compared between the P-DA and control groups. RESULT AND

conclusionThis mixed methods extended follow-up study will provide data on long term outcomes, relating to the use of a computerized P-DA in decision-making about adjuvant RAI treatment in early stage papillary thyroid cancer. DISCUSSION: Our results are intended to inform future research in this area, particularly relating to long term effects of the use of P-DAs in making healthcare choices.

trial registrationClinicaltrials.gov identifier NCT01083550, registered 24 February 2010 and last updated 5 January 2015.

Indexed as

Decision Support Systems, ClinicalDecision Support TechniquesPatient ParticipationCarcinomaCarcinoma, PapillaryChoice BehaviorClinical ProtocolsFollow-Up StudiesHealth Knowledge, Attitudes, PracticeHealth LiteracyHumansIodine RadioisotopesNeoplasm StagingOntarioPredictive Value of TestsRadiopharmaceuticalsIodine RadioisotopesRadiopharmaceuticals

Identifiers

PMID26169592
PMCPMC4501089
OpenAlexW1621933855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.