ArticleAnnals of vascular surgery2016
Amputation Risk in Patients with Diabetes Mellitus and Peripheral Artery Disease Using Statewide Data.
Article in Annals of vascular surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline.The Journal of clinical endocrinology and metabolism · 2019Guideline
- Acute on Chronic Diabetic Forefoot Osteomyelitis Treated With Internal Pedal Amputation and Cement: A Preliminary Report.Foot & ankle orthopaedics · 2025Article
- Smoking Status Impacts Mitochondrial Function and Synthetic Function in Mesenchymal Stem Cells Derived from Diabetics with Arterial Insufficiency.Advances in wound care · 2025Article
- The contemporary natural history of minor amputation among diabetic patients with peripheral arterial disease.Journal of vascular surgery · 2025Article
- Peripheral neuropathy prevalence and effect on mobility 12 months after prosthesis prescription among individuals with dysvascular lower extremity amputation.PM & R : the journal of injury, function, and rehabilitation · 2025Article
- Inflammatory Markers Used as Predictors of Subclinical Atherosclerosis in Patients with Diabetic Polyneuropathy.Life (Basel, Switzerland) · 2023Article
- Trends of Concomitant Diabetes and Peripheral Artery Disease and Lower Extremity Amputation in US Medicare Patients, 2007 to 2019.Circulation. Cardiovascular quality and outcomes · 2023Article
- Cross Talks between Oxidative Stress, Inflammation and Epigenetics in Diabetic Retinopathy.Cells · 2023Review
- Apelin prevents diabetes-induced poor collateral vessel formation and blood flow reperfusion in ischemic limb.Frontiers in cardiovascular medicine · 2023Article
- Temporal trends in patients with peripheral artery disease influenced by diabetes mellitus in Germany.Journal of diabetes · 2022Article
- Trends of limb amputation considering type, level, sex and age in Saskatchewan, Canada 2006-2019: an in-depth assessment.Archives of public health = Archives belges de sante publique · 2022Article
- Non-Hispanic Black and Hispanic Patients Have Worse Outcomes Than White Patients Within Similar Stages of Peripheral Artery Disease.Journal of the American Heart Association · 2022Article
- Infrared Thermography as a Diagnostic Tool for the Assessment of Patients with Symptomatic Peripheral Arterial Disease Undergoing Infrafemoral Endovascular Revascularisations.Diagnostics (Basel, Switzerland) · 2021Article
- Incidence and trends of limb amputation in first nations and general population in Saskatchewan, 2006-2019.PloS one · 2021Article
- Epidemiology and Risk of Amputation in Patients With Diabetes Mellitus and Peripheral Artery Disease.Arteriosclerosis, thrombosis, and vascular biology · 2020Article
- Incidence of lower extremity amputations among patients with type 1 and type 2 diabetes in the United States from 2010 to 2014.Diabetes, obesity & metabolism · 2020Article
- Rates and timing of subsequent amputation after initial minor amputation.Journal of vascular surgery · 2020Article
- Endovascular-First Treatment Is Associated With Improved Amputation-Free Survival in Patients With Critical Limb Ischemia.Circulation. Cardiovascular quality and outcomes · 2019Article
- Review
- [Operative treatment of diabetics with vascular complications : Secondary data analysis of diagnosis-related groups statistics from 2005 to 2014 in Germany].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundConflicting data exist regarding changes in amputation rates in patients with ulcers because of diabetes mellitus (DM) and peripheral artery disease (PAD). This study focuses on how population-based amputation rates are changing in the current treatment era.
methodsUsing the California Office of Statewide Health Planning and Development Patient Discharge database, all patients who underwent major nontraumatic lower extremity (LE) amputation in 2005 through 2011 were identified. Age-adjusted population-based amputation risk was determined by year. Gender and age trends in amputation risk were estimated separately for diabetes-related amputations and PAD-related amputations, treating all California residents as the population at risk.
resultsFrom 2005 to 2011, 32,025 qualifying amputations were performed in California. Of these, 11,896 were DM-associated (n = 1,095), PAD-associated (n = 4,335), or associated with both conditions (n = 6,466). PAD-associated amputation rates and combined PAD/DM-associated amputation rates have changed little since 2009 after decreasing substantially over the prior 5 years, but DM-associated amputation rates have continuously increased since 2005. California residents older than the age of 80 years had the most dramatic decrease in PAD-associated amputation rates from 2005 to 2011 (i.e., from 317 to 175 per million Californians). Men with PAD/DM had amputation rate 1.5 times higher than those of patients with PAD alone and 5 times higher than rates of DM patients. In women the difference between patient with PAD and PAD/DM was not seen; however, these rates were 2.5 times higher than patients with DM alone.
conclusionsPreventable amputations associated with high-risk diseases are no longer decreasing despite continuing advances in care and education. Octogenarians with PAD represent the highest risk group for amputation, but DM-associated amputations have increased since 2005. Further research to understand treatment pathways for patient with LE wounds may shed light on pathways for amputation prevention in the future.
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