ArticleAntimicrobial agents and chemotherapy2015
Phylogeny and Comparative Genomics Unveil Independent Diversification Trajectories of qnrB and Genetic Platforms within Particular Citrobacter Species.
Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed.
- From environmental reservoirs to clinical threats: the expanding resistome and genetic plasticity of Citrobacter spp.Infection · 2026Review
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- The phylogenomic landscape of extended-spectrum β-lactamase producing Citrobacter species isolated from surface water.BMC genomics · 2023Article
- Phenotypic and Genotypic Characteristics of Antimicrobial Resistance inAntibiotics (Basel, Switzerland) · 2023Article
- Evidence for wastewaters as environments where mobile antibiotic resistance genes emerge.Communications biology · 2023Article
- Aquatic Environments as Hotspots of Transferable Low-Level Quinolone Resistance and Their Potential Contribution to High-Level Quinolone Resistance.Antibiotics (Basel, Switzerland) · 2022Review
- Characterization of a Novel Variant of the Quinolone-Resistance GeneAntibiotics (Basel, Switzerland) · 2021Article
- Long-term stability of the urogenital microbiota of asymptomatic European women.BMC microbiology · 2021Article
- Article
- A framework for identifying the recent origins of mobile antibiotic resistance genes.Communications biology · 2021Article
- Allogenous Selection of Mutational Collateral Resistance: Old Drugs Select for New Resistance Within Antibiotic Families.Frontiers in microbiology · 2021Review
- Citrobacter telavivum sp. nov. with chromosomal mcr-9 from hospitalized patients.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Characterization of Antimicrobial Resistance inMicroorganisms · 2019Article
- Article
- Isolation of five Enterobacteriaceae species harbouring blaNDM-1 and mcr-1 plasmids from a single paediatric patient.PloS one · 2019Article
- In Vitro Susceptibility and Florfenicol Resistance inInternational journal of genomics · 2019Article
- Comparative Genomic Analysis ofFrontiers in microbiology · 2019Article
- Diverse Fluoroquinolone Resistance Plasmids From Retail MeatFrontiers in microbiology · 2019Article
- High prevalence of carriage ofEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2018Article
- Article
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Abstract
To gain insights into the diversification trajectories of qnrB genes, a phylogenetic and comparative genomics analysis of these genes and their surrounding genetic sequences was performed. For this purpose, Citrobacter sp. isolates (n = 21) and genome or plasmid sequences (n = 56) available in public databases harboring complete or truncated qnrB genes were analyzed. Citrobacter species identification was performed by phylogenetic analysis of different genotypic markers. The clonal relatedness among isolates, the location of qnrB genes, and the genetic surroundings of qnrB genes were investigated by pulsed-field gel electrophoresis (PFGE), S1-/I-CeuI-PFGE and hybridization, and PCR mapping and sequencing, respectively. Identification of Citrobacter isolates was achieved using leuS and recN gene sequences, and isolates characterized in this study were diverse and harbored chromosomal qnrB genes. Phylogenetic analysis of all known qnrB genes revealed seven main clusters and two branches, with most of them included in two clusters. Specific platforms (comprising pspF and sapA and varying in synteny and/or identity of other genes and intergenic regions) were associated with each one of these qnrB clusters, and the reliable identification of all Citrobacter isolates revealed that each platform evolved in different recognizable (Citrobacter freundii, C. braakii, C. werkmanii, and C. pasteurii) and putatively new species. A high identity was observed between some of the platforms identified in the chromosome of Citrobacter spp. and in different plasmids of Enterobacteriaceae. Our data corroborate Citrobacter as the origin of qnrB and further suggest divergent evolution of closely related qnrB genes/platforms in particular Citrobacter spp., which were delineated using particular genotypic markers.
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