ArticleScientific reports2015
Studying biological membranes with extended range high-speed atomic force microscopy.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Feedforward compensation of piezo nonlinearity for high-precision high-speed atomic force microscopy.Scientific reports · 2026Article
- Enhanced feedback performance in off-resonance AFM modes through pulse train sampling.Beilstein journal of nanotechnology · 2024Article
- Spatiotemporal resolution in high-speed atomic force microscopy for studying biological macromolecules in action.Microscopy (Oxford, England) · 2023Review
- Acceleration of imaging in atomic force microscopy working in sub-resonance tapping mode.The Review of scientific instruments · 2022Article
- Sensing red blood cell nano-mechanics: Toward a novel blood biomarker for Alzheimer's disease.Frontiers in aging neuroscience · 2022Article
- A cantilever-based, ultrahigh-vacuum, low-temperature scanning probe instrument for multidimensional scanning force microscopy.Beilstein journal of nanotechnology · 2022Article
- Heterogeneity in Lateral Distribution of Polycations at the Surface of Lipid Membrane: From the Experimental Data to the Theoretical Model.Materials (Basel, Switzerland) · 2021Review
- An atomic force microscope integrated with a helium ion microscope for correlative nanoscale characterization.Beilstein journal of nanotechnology · 2020Article
- Photothermal Off-Resonance Tapping for Rapid and Gentle Atomic Force Imaging of Live Cells.International journal of molecular sciences · 2018Article
- High-speed photothermal off-resonance atomic force microscopy reveals assembly routes of centriolar scaffold protein SAS-6.Nature nanotechnology · 2018Article
- Functional expression of the entire adhesiome of Salmonella enterica serotype Typhimurium.Scientific reports · 2017Article
- Vibrational Profiling of Brain Tumors and Cells.Theranostics · 2017Article
- Harnessing the damping properties of materials for high-speed atomic force microscopy.Nature nanotechnology · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
High-speed atomic force microscopy has proven to be a valuable tool for the study of biomolecular systems at the nanoscale. Expanding its application to larger biological specimens such as membranes or cells has, however, proven difficult, often requiring fundamental changes in the AFM instrument. Here we show a way to utilize conventional AFM instrumentation with minor alterations to perform high-speed AFM imaging with a large scan range. Using a two-actuator design with adapted control systems, a 130 × 130 × 5 μm scanner with nearly 100 kHz open-loop small-signal Z-bandwidth is implemented. This allows for high-speed imaging of biologically relevant samples as well as high-speed measurements of nanomechanical surface properties. We demonstrate the system performance by real-time imaging of the effect of charged polymer nanoparticles on the integrity of lipid membranes at high imaging speeds and peak force tapping measurements at 32 kHz peak force rate.
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