ArticleCancer causes & control : CCC2015
The metabolic syndrome and mammographic breast density in a racially diverse and predominantly immigrant sample of women.
Article in Cancer causes & control : CCC, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Systematic Review and Meta-Analysis of Metabolic Syndrome and Its Components in Latino Immigrants to the USA.International journal of environmental research and public health · 2023Pooled it
- Untargeted serum metabolomic profiles and breast density in young women.Cancer causes & control : CCC · 2024Article
- Association of mammographic density and benign breast calcifications individually or combined with hypertension, diabetes, and hypercholesterolemia in women ≥40 years of age: a retrospective study.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2022Article
- The epidemiologic factors associated with breast density: A review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2022Review
- Clinical Factors Associated with Asymptomatic Women Having Inconclusive Screening Mammography Results: Experiences from a Single Medical Center in Taiwan.International journal of environmental research and public health · 2021Article
- Metabolic Syndrome in Breast Cancer Patients: An Observational Study.Breast cancer : basic and clinical research · 2021Article
- Independent and joint cross-sectional associations of statin and metformin use with mammographic breast density.Breast cancer research : BCR · 2020Article
- Associations of Nativity, Age at Migration, and Percent of Life in the U.S. with Midlife Body Mass Index and Waist Size in New York City Latinas.International journal of environmental research and public health · 2020Article
- Mammographic densities of Aboriginal and non-Aboriginal women living in Australia's Northern Territory.International journal of public health · 2019Article
- "You probably can't feel as safe as normal women": Hispanic women's reactions to breast density notification.Cancer · 2019Article
- Childhood body size and midlife mammographic breast density in foreign-born and U.S.-born women in New York City.Annals of epidemiology · 2018Article
- Gestational diabetes, type II diabetes, and mammographic breast density in a U.S. racially diverse population screened for breast cancer.Cancer causes & control : CCC · 2018Article
- Predictors of Breast Cancer Worry in a Hispanic and Predominantly Immigrant Mammography Screening Population.Women's health issues : official publication of the Jacobs Institute of Women's HealthArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
purposeThe metabolic syndrome [MetS, clustering of elevated blood pressure, triglycerides and glucose, reduced high-density lipoprotein cholesterol (HDL-C), abdominal obesity] has been associated with increased breast cancer risk, but less is known about its association with mammographic breast density, a strong risk factor for breast cancer.
methodsWe collected data on risk factors, body size, and blood pressure via in-person interviews and examinations and measured glucose, triglycerides, and HDL-C from dried blood spots from women recruited through a mammography screening clinic (n = 373; 68 % Hispanic, 17 % African-American, 63 % foreign born). We performed linear regression models to examine the associations of each MetS component and the MetS cluster (≥3 components) with percent density and dense breast area, measured using a computer-assisted technique and Cumulus software.
resultsAbout 45 % of women had the MetS, with the prevalence of the individual components ranging from 68 % for abdominal obesity to 33 % for elevated triglycerides. The prevalence of the MetS increased with higher body mass index (BMI) and postmenopausal status, but did not vary substantially by ethnicity, immigrant generational status, parity, age at menarche, or alcohol consumption. Low HDL-C (<50 mg/dL), but not the MetS cluster or the other MetS components, was associated with larger dense breast area after adjusting for age, BMI, fasting time, and educational attainment (β = 8.77, 95 % CI 2.39, 15.14). The MetS and its individual components were not associated with BMI-adjusted percent density.
conclusionsHDL-C alone may have an influence on dense breast tissue that is independent of BMI, and may be in the same direction as its association with breast cancer risk.
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