ArticleHypertension (Dallas, Tex. : 1979)2015
Ethnic Differences in Associations Between Blood Pressure and Stroke in South Asian and European Men.
Article in Hypertension (Dallas, Tex. : 1979), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 6 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 6 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Prevalence and trends of hypertension among South Asian adults: a systematic review and meta-analysis.Journal of human hypertension · 2026Pooled it
- Relationship between sublingual varices and hypertension: a systematic review and meta-analysis.BMC oral health · 2024Pooled it
- Ethnic inequalities in multiple long-term health conditions in the United Kingdom: a systematic review and narrative synthesis.BMC public health · 2023Pooled it
- Comparison Between Automated Office Blood Pressure Measurements and Manual Office Blood Pressure Measurements-Implications in Individual Patients: a Systematic Review and Meta-analysis.Current hypertension reports · 2021Pooled it
- Heterogeneity in blood pressure in UK Bangladeshi, Indian and Pakistani, compared to White, populations: divergence of adults and children.Journal of human hypertension · 2018Pooled it
- Systematic review: antihypertensive drug therapy in patients of African and South Asian ethnicity.Internal and emergency medicine · 2016Pooled it
- Associations of social and economic and pregnancy exposures with blood pressure in UK White British and Pakistani children age 4/5.Scientific reports · 2018Trial
- Effect of acupuncture on ischemic stroke patients with hypertension: a randomized clinical trail.Frontiers in neurologyTrial
- A flexible and unified framework for single- and multi-outcome Mendelian randomization using summary statistics.American journal of human genetics · 2026Article
- Identifying barriers to the acceptability and adoption of ambulatory blood pressure monitoring and proposed strategies in Bangladesh, Pakistan, and Sri Lanka: a qualitative study.BMC health services research · 2026Article
- Limitations and Blind Spots of Diffusion-Weighted Imaging in the Evaluation of Acute Brain Ischemia: A Narrative Review.Journal of clinical medicine · 2026Review
- Heterogeneity in the development of diabetes-related complications: narrative review of the roles of ancestry and geographical determinants.Diabetologia · 2025Review
- Metabolic Syndrome and Risk of Moyamoya Vasculopathy and Subsequent Stroke in Young Adults.Journal of the American Heart Association · 2025Article
- Twelve-year nationwide cohort study identifying risk factors for conversion from mild cognitive impairment to Alzheimer's disease.Scientific reports · 2025Article
- Second home blood pressure measurements per occasion predict incident cardiovascular events in type 2 diabetes: KAMOGAWA-HBP study.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Burden of cardiovascular disease attributable to risk factors in Pakistan: insight from Global Burden of Disease Study 2019.Proceedings (Baylor University. Medical Center) · 2025Article
- Ambulatory blood pressure levels in individuals with uncontrolled clinic hypertension across Bangladesh, Pakistan, and Sri Lanka.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Management of Hypertension in the Asia-Pacific Region: A Structured Review.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2024Review
- Ethnicity-specific blood pressure thresholds based on cardiovascular and renal complications: a prospective study in the UK Biobank.BMC medicine · 2024Article
- Association between metabolic syndrome and stroke: a population based cohort study.BMC endocrine disorders · 2023Article
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Abstract
It is unknown whether associations between blood pressure (BP) and stroke vary between Europeans and South Asians, despite higher stroke rates in the latter. We report findings from a UK cohort study of 1375 European and 1074 South Asian men, not receiving antihypertensive medication, aged 40 to 69 years at baseline (1988-1991). Assessment included BP, blood tests, anthropometry, and questionnaires. Incident stroke was established at 20 years from death certification, hospital and primary care records, and participant report. South Asians had higher systolic BP, diastolic BP, and mean arterial pressure than Europeans, and similar pulse pressure. Associations between systolic BP or diastolic BP and stroke were stronger in South Asians than Europeans, after adjustment for age, smoking status, waist/hip ratio, total/high-density lipoprotein-cholesterol ratio, diabetes mellitus, fasting glucose, physical activity, and heart rate (systolic BP: Europeans [odds ratio, 1.22; 95% confidence interval, 0.98-1.51], South Asians [1.56; 1.24-1.95]; ethnic difference P=0.04; diastolic BP: Europeans [0.90; 0.71-1.13], South Asians [1.68; 1.32-2.15]; P<0.001). Hemodynamic correlates of stroke risk differed by ethnicity: in combined models, mean arterial pressure but not pulse pressure was detrimentally associated with stroke in South Asians, whereas the converse was true for Europeans. The combination of hyperglycemia and hypertension appeared particularly detrimental for South Asians. There are marked ethnic differences in associations between BP parameters and stroke. Undue focus on systolic BP for risk prediction, and current age and treatment thresholds may be inappropriate for individuals of South Asian ancestry.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.