ArticleInternational journal of psychophysiology : official journal of the International Organization of Psychophysiology2015
Time course of threat responding in panic disorder and depression.
Article in International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The novel vasopressin receptor (V1aR) antagonist SRX246 reduces anxiety in an experimental model in humans: a randomized proof-of-concept study.Psychopharmacology · 2021Trial
- Transdiagnostic Fear and Anxiety: Prospective Prediction Using the No-Threat, Predictable Threat, and Unpredictable Threat Task.Biological psychiatry global open science · 2023Article
- Continuous Theta-Burst Stimulation to the Right Dorsolateral Prefrontal Cortex May Increase Potentiated Startle in Healthy Individuals.Biological psychiatry global open science · 2023Article
- Associations Between Repetitive Negative Thinking and Habituation of Defensive Responding Within and Between Sessions.Affective science · 2022Article
- Event-related potentials to acoustic startle probes during unpredictable threat are associated with individual differences in intolerance of uncertainty.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2022Article
- Ethnic differences in behavioral and physiological indicators of sensitivity to threat.Journal of anxiety disorders · 2022Article
- Low-frequency parietal repetitive transcranial magnetic stimulation reduces fear and anxiety.Translational psychiatry · 2020Article
- Modeling anxiety in healthy humans: a key intermediate bridge between basic and clinical sciences.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- The time course of responding to aversiveness in females with a history of non-suicidal self-injury.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2019Article
- Neural correlates of predictable and unpredictable threat in internalizing psychopathology.Neuroscience letters · 2019Article
- Brain Correlates of Continuous Pain in Rheumatoid Arthritis as Measured by Pulsed Arterial Spin Labeling.Arthritis care & research · 2019Article
- Exercise decreases defensive responses to unpredictable, but not predictable, threat.Depression and anxiety · 2018Article
- The effect of panic disorder versus anxiety sensitivity on event-related potentials during anticipation of threat.Journal of anxiety disorders · 2018Article
- Using Event-Related Potentials and Startle to Evaluate Time Course in Anxiety and Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Review
- How many blinks are necessary for a reliable startle response? A test using the NPU-threat task.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- Startle potentiation to uncertain threat as a psychophysiological indicator of fear-based psychopathology: An examination across multiple internalizing disorders.Journal of abnormal psychology · 2017Article
- Association between problematic alcohol use and reactivity to uncertain threat in two independent samples.Drug and alcohol dependence · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Heightened sensitivity to threat is a characteristic feature of panic disorder (PD). It is also a factor that is considered to be central to PD but not major depressive disorder (MDD) – a related disorder that commonly co-occurs with PD. However, sensitivity to threat is a broad construct and it is unclear whether individuals with PD exhibit heightened initial threat reactivity, impairments in modulating their threat responding over time, or both. It is also unclear how these different facets of threat responding apply to predictable and/or unpredictable threat. The aim of the current study was to examine whether there are differences in initial threat reactivity and the time course of threat responding during predictable and unpredictable threat-of-shock in 186 adults with: 1) current PD and no history of depression (i.e., PD-only), 2) current MDD and no history of an anxiety disorder (i.e., MDD-only), 3) current comorbid PD and MDD, or 4) no lifetime history of psychopathology (i.e., controls). Threat responding was assessed using an electromyography startle paradigm. Relative to controls, individuals in the three psychopathology groups exhibited heightened initial threat reactivity to predictable and unpredictable threat and did not differ from each other. Multilevel mixed model analyses indicated that those with PD evidenced less of a decline over time in startle responding during unpredictable threat relative to those without PD. Those with MDD displayed a greater slope of decline in startle responding during predictable threat compared with those without MDD. The pattern of results suggests that there may be conceptual differences between measures of initial threat reactivity and time course of threat responding. Moreover, time course of threat responding, not initial threat reactivity, may differentiate PD from MDD.
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