ArticleNeuroscience2015
Cross-frequency coupling in deep brain structures upon processing the painful sensory inputs.
Article in Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03739645 (Physiological Studies in Healthy Subjects, Chronic Pain Patients and in Patients Undergoing Neurosurgical Procedures of Human Forebrain Mechanisms Mediating Somatic Sensation, Motor Control and Neurological Disorders), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physiological Studies in Healthy Subjects, Chronic Pain Patients and in Patients Undergoing Neurosurgical Procedures of Human Forebrain Mechanisms Mediating Somatic Sensation, Motor Control and Neurological Disorders
Who cites it
19 citing papers in PubMed.
- Article
- EEG-based clustering shows distinct separation of chronic pain patients before spinal cord stimulation surgery.NeuroImage · 2026Article
- Predicting Pain: Electroencephalography Signatures of Neural Integration During Experimental Tonic Thermal Pain.European journal of pain (London, England) · 2026Article
- What can neurofeedback and transcranial alternating current stimulation reveal about cross-frequency coupling?Frontiers in neuroscience · 2025Article
- Resting state EEG delta-beta amplitude-amplitude coupling: a neural predictor of cortisol response under stress.Cognitive neurodynamics · 2024Article
- Validity of central pain processing biomarkers for predicting the occurrence of oncological chronic pain: a study protocol.BMC cancer · 2024Article
- Cross-Frequency Coupling and Intelligent Neuromodulation.Cyborg and bionic systems (Washington, D.C.) · 2023Review
- Structural and Functional Asymmetry in Precentral and Postcentral Gyrus in Patients With Unilateral Chronic Shoulder Pain.Frontiers in neurology · 2022Article
- Theta-gamma coupling as a cortical biomarker of brain-computer interface-mediated motor recovery in chronic stroke.Brain communications · 2022Article
- Cortical Cross-Frequency Coupling Is Affected byFrontiers in neuroscience · 2022Article
- Behavioral, Physiological and EEG Activities Associated with Conditioned Fear as Sensors for Fear and Anxiety.Sensors (Basel, Switzerland) · 2020Review
- A Deep Brain Stimulation Trial Period for Treating Chronic Pain.Journal of clinical medicine · 2020Review
- High Cervical Spinal Cord Stimulation: A One Year Follow-Up Study on Motor and Non-Motor Functions in Parkinson's Disease.Brain sciences · 2019Article
- Cortical Pain Processing in the Rat Anterior Cingulate Cortex and Primary Somatosensory Cortex.Frontiers in cellular neuroscience · 2019Article
- Analgesic Effects of Compression at Trigger Points Are Associated With Reduction of Frontal Polar Cortical Activity as Well as Functional Connectivity Between the Frontal Polar Area and Insula in Patients With Chronic Low Back Pain: A Randomized Trial.Frontiers in systems neuroscience · 2019Article
- Electroacupuncture Treatment Alleviates the Remifentanil-Induced Hyperalgesia by Regulating the Activities of the Ventral Posterior Lateral Nucleus of the Thalamus Neurons in Rats.Neural plasticity · 2018Article
- Oscillatory EEG activity induced by conditioning stimuli during fear conditioning reflects Salience and Valence of these stimuli more than Expectancy.Neuroscience · 2017Article
- Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Enhanced Gamma Oscillatory Activity in Rats with Chronic Inflammatory Pain.Frontiers in neuroscience · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Cross-frequency coupling has been shown to be functionally significant in cortical information processing, potentially serving as a mechanism for integrating functionally relevant regions in the brain. In this study, we evaluate the hypothesis that pain-related gamma oscillatory responses are coupled with low-frequency oscillations in the frontal lobe, amygdala and hippocampus, areas known to have roles in pain processing. We delivered painful laser pulses to random locations on the dorsal hand of five patients with uncontrolled epilepsy requiring depth electrode implantation for seizure monitoring. Two blocks of 40 laser stimulations were delivered to each subject and the pain-intensity was controlled at five in a 0-10 scale by adjusting the energy level of the laser pulses. Local-field-potentials (LFPs) were recorded through bilaterally implanted depth electrode contacts to study the oscillatory responses upon processing the painful laser stimulations. Our results show that painful laser stimulations enhanced low-gamma (LH, 40-70 Hz) and high-gamma (HG, 70-110 Hz) oscillatory responses in the amygdala and hippocampal regions on the right hemisphere and these gamma responses were significantly coupled with the phases of theta (4-7 Hz) and alpha (8-1 2 Hz) rhythms during pain processing. Given the roles of these deep brain structures in emotion, these findings suggest that the oscillatory responses in these regions may play a role in integrating the affective component of pain, which may contribute to our understanding of the mechanisms underlying the affective information processing in humans.
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Registered trials
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