ArticleEndocrinology2015
Sex Differences in Somatotrope Dependency on Leptin Receptors in Young Mice: Ablation of LEPR Causes Severe Growth Hormone Deficiency and Abdominal Obesity in Males.
Article in Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 29 citations in OpenAlex.
- Integrated pituitary adaptations to the low estrogen state.Frontiers in endocrinology · 2026Article
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice.Endocrinology · 2025Article
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes.Frontiers in endocrinology · 2025Article
- Characterization and Regulation of the Neonatal Growth Hormone Surge.Endocrinology · 2024Article
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs.Scientific reports · 2024Article
- Single-Cell Transcriptomics Identifies Pituitary Gland Changes in Diet-Induced Obesity in Male Mice.Endocrinology · 2024Article
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism.Endocrinology · 2023Article
- Influence of Leptin on the Secretion of Growth Hormone in Ewes under Different Photoperiodic Conditions.International journal of molecular sciences · 2023Article
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain.Frontiers in endocrinology · 2023Article
- Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi.Endocrinology · 2021Article
- Sex differences in somatotrope response to fasting: biphasic responses in male mice.The Journal of endocrinology · 2020Article
- Metabolic signalling to somatotrophs: Transcriptional and post-transcriptional mediators.Journal of neuroendocrinology · 2020Article
- Early overnutrition sensitizes the growth hormone axis to the impact of diet-induced obesity via sex-divergent mechanisms.Scientific reports · 2020Article
- 'Fat's chances': Loci for phenotypic dispersion in plasma leptin in mouse models of diabetes mellitus.PloS one · 2019Article
- Sex-specific changes in postnatal GH and PRL secretion in somatotrope LEPR-null mice.The Journal of endocrinology · 2018Article
- Appetite, Metabolism and Hormonal Regulation in Normal Ageing and Dementia.Diseases (Basel, Switzerland) · 2018Review
- Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression.Endocrinology · 2018Article
- Association of polymorphisms in LEPR with type 2 diabetes and related metabolic traits in a Chinese population.Lipids in health and disease · 2018Article
- Manipulation of the Growth Hormone-Insulin-Like Growth Factor (GH-IGF) Axis: A Treatment Strategy to Reverse the Effects of Early Life Developmental Programming.International journal of molecular sciences · 2017Review
- Delta-like protein 1 in the pituitary-adipose axis in the adult male mouse.Journal of neuroendocrinology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Leptin receptor (LEPR) signaling controls appetite and energy expenditure. Somatotrope-specific deletion of the LEPRb signaling isoform causes GH deficiency and obesity. The present study selectively ablated Lepr exon 1 in somatotropes, which removes the signal peptide, causing the loss of all isoforms of LEPR. Excision of Lepr exon 1 was restricted to the pituitary, and mutant somatotropes failed to respond to leptin. Young (2-3 mo) males showed a severe 84% reduction in serum GH levels and more than 60% reduction in immunolabeled GH cells compared with 41%-42% reductions in GH and GH cells in mutant females. Mutant males (35 d) and females (45 d) weighed less than controls and males had lower lean body mass. Image analysis of adipose tissue by magnetic resonance imaging showed that young males had a 2-fold increase in abdominal fat mass and increased adipose tissue density. Young females had only an overall increase in adipose tissue. Both males and females showed lower energy expenditure and higher respiratory quotient, indicating preferential carbohydrate burning. Young mutant males slept less and were more restless during the dark phase, whereas the opposite was true of females. The effects of a Cre-bearing sire on his non-Cre-recombinase bearing progeny are seen by increased respiratory quotient and reduced litter sizes. These studies elucidate clear sex differences in the extent to which somatotropes are dependent on all isoforms of LEPR. These results, which were not seen with the ablation of Lepr exon 17, highlight the severe consequences of ablation of LEPR in male somatotropes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.