Evidence map›Paper›PMID 26168262›Full record

Trial reportJournal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)2015

Decreases in perceived maternal criticism predict improvement in subthreshold psychotic symptoms in a randomized trial of family-focused therapy for individuals at clinical high risk for psychosis.

Mary P O'Brien, David J Miklowitz, Tyrone D Cannon

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04338152 (Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04338152 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy Trial

TypeinterventionalSponsorUniversity of California, Los AngelesRan2021 to 2026Enrolled220ConditionsPsychotic Disorders, Prodromal Symptoms, Prodromal Schizophrenia, PsychosisArmsFamily Focused Therapy for Clinical High Risk Youth (FFT-CHR), Enhanced Care (EC)
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Interventions for prodromal stage of psychosis.The Cochrane database of systematic reviews · 2019
    Pooled it
  3. Trajectories of parent criticism across treatment for youth self-harm.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Family communication with teens at clinical high-risk for psychosis or bipolar disorder.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2018
    Trial
  9. Article
  10. Synergistic pathways to psychosis: understanding developmental risk and resilience factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mary P O'BrienDepartment of Psychiatry, University of California, Los Angeles, School of Medicine.
David J MiklowitzDepartment of Psychiatry, University of California, Los Angeles, School of Medicine.
Tyrone D CannonDepartment of Psychiatry, University of California, Los Angeles.

Funding

1/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2016
$3.6M
Prevention Trial of Family Focused Treatment in Youth at Risk for PsychosisRC1MH088546 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CANNON, TYRONE D · 2009 to 2010
$970k
Family-Focused Therapy for Youth with Early-Onset Bipolar or Psychotic Disorders R33MH097007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2014 to 2016
$853k
Family-Focused Treatment for Youth with Early-Onset Bipolar or Psychotic DisorderR21MH097007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2013
$439k
NIMH NIH HHS R01 MH093676NIMH NIH HHS R21 MH097007NIMH NIH HHS R33 MH097007NIMH NIH HHS RC1 MH088546
6 · The paper itself

Abstract

Perceived criticism (PC) is a measure of how much criticism from 1 family member "gets through" to another. PC ratings have been found to predict the course of psychotic disorders, but questions remain regarding whether psychosocial treatment can effectively decrease PC, and whether reductions in PC predict symptom improvement. In a sample of individuals at high risk for psychosis, we examined a) whether Family Focused Therapy for Clinical High-Risk (FFT-CHR), an 18-session intervention that consists of psychoeducation and training in communication and problem solving, brought about greater reductions in perceived maternal criticism, compared to a 3-session family psychoeducational intervention; and b) whether reductions in PC from baseline to 6-month reassessment predicted decreases in subthreshold positive symptoms of psychosis at 12-month follow-up. This study was conducted within a randomized controlled trial across 8 sites. The perceived criticism scale was completed by 90 families prior to treatment and by 41 families at 6-month reassessment. Evaluators, blind to treatment condition, rated subthreshold symptoms of psychosis at baseline, 6- and 12-month assessments. Perceived maternal criticism decreased from pre- to posttreatment for both treatment groups, and this change in criticism predicted decreases in subthreshold positive symptoms at 12-month follow-up. This study offers evidence that participation in structured family treatment is associated with improvement in perceptions of the family environment. Further, a brief measure of perceived criticism may be useful in predicting the future course of attenuated symptoms of psychosis for CHR youth.

Indexed as

Family TherapyPerceptionAdolescentAdultChildFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMother-Child RelationsMothersPsychotic DisordersRiskTreatment OutcomeYoung Adult

Identifiers

PMID26168262
PMCPMC4673032

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.