ReviewHormone molecular biology and clinical investigation2015
A weighty problem: metabolic perturbations and the obesity-cancer link.
Review in Hormone molecular biology and clinical investigation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Adipocytokines and disease progression in endometrial cancer: a systematic review.Cancer metastasis reviews · 2022Pooled it
- Using a cultural dance program to increase sustainable physical activity for breast cancer survivors-A pilot study.Complementary therapies in medicine · 2019Trial
- Observational
- Metabolome-Wide Mendelian Randomization Identifies Maleate as a Mediator of the Effect of Obesity on the Risk of Small Cell Lung Cancer.Food science & nutrition · 2025Article
- Adiposity, metabolites and endometrial cancer risk: inference from combinations of Mendelian randomization and observational analyses.BMC cancer · 2025Observational
- Unraveling molecular interconnections and identifying potential therapeutic targets of significance in obesity-cancer link.Journal of the National Cancer Center · 2025Review
- Review
- Macronutrient-differential dietary pattern impacts on body weight, hepatic inflammation, and metabolism.Frontiers in nutrition · 2024Article
- Obesity and cancer: focus on leptin.Molecular biology reports · 2023Review
- A Metabolomic Signature of Obesity and Risk of Colorectal Cancer: Two Nested Case-Control Studies.Metabolites · 2023Article
- Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- How Childhood Socioeconomic Status Impacts Adult Food Preference: The Mediating Role of Stress and Trait Appetite.Behavioral sciences (Basel, Switzerland) · 2022Article
- Preventing ovariectomy-induced weight gain decreases tumor burden in rodent models of obesity and postmenopausal breast cancer.Breast cancer research : BCR · 2022Article
- Mitochondrial-Dependent and Independent Functions of PINK1.Frontiers in cell and developmental biology · 2022Review
- Identification of gene signature in RNA-Seq hepatocellular carcinoma data by Pareto-optimal cluster algorithm.Gastroenterology and hepatology from bed to bench · 2022Article
- Obesity as potential breast cancer risk factor for postmenopausal women.Genes & diseases · 2021Review
- The Cancer Cell Dissemination Machinery as an Immunosuppressive Niche: A New Obstacle Towards the Era of Cancer Immunotherapy.Frontiers in immunology · 2021Review
- Milestones in DRI Development: What Does the Future Hold?Advances in nutrition (Bethesda, Md.) · 2019Article
- Senolytics and senostatics as adjuvant tumour therapy.EBioMedicine · 2019Review
- Reversal of obesity-driven aggressiveness of endometrial cancer by metformin.American journal of cancer research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Obesity is an established risk factor for several cancers, including breast, colon, endometrial, ovarian, gastric, pancreatic and liver, and is increasingly a public health concern. Obese cancer patients often have poorer prognoses, reduced response to standard treatments, and are more likely to develop metastatic disease than normo-weight individuals. Many of the pathologic features of obesity promote tumor growth, such as metabolic perturbations, hormonal and growth factor imbalances, and chronic inflammation. Although obesity exacerbates tumor development, the interconnected relationship between the two conditions presents opportunities for new treatment approaches, some of which may be more successful in obese cohorts. Here, we discuss the many ways in which excess adiposity can impact cancer development and progression and address potential preventive and therapeutic strategies to reduce the burden of obesity-related cancers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.