ArticleNature neuroscience2015
Coexpression networks identify brain region-specific enhancer RNAs in the human brain.
Article in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comprehensive multi-omics integration identifies differentially active enhancers during human brain development with clinical relevance.Genome medicine · 2021Pooled it
- Deciphering the regulatory landscape of enhancer RNAs in health and disease.Signal transduction and targeted therapy · 2026Review
- eRNA-IDO: A One-stop Platform for Identification, Interactome Discovery, and Functional Annotation of Enhancer RNAs.Genomics, proteomics & bioinformatics · 2024Article
- Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers.Military Medical Research · 2024Article
- An Emerging Role for Enhancer RNAs in Brain Disorders.Neuromolecular medicine · 2024Review
- Molecular mechanisms of microbiome modulation by the eukaryotic secondary metabolite azelaic acid.eLife · 2024Article
- eRNAbase: a comprehensive database for decoding the regulatory eRNAs in human and mouse.Nucleic acids research · 2024Article
- Possible roles of deep cortical neurons and oligodendrocytes in the neural basis of human sociality.Anatomical science international · 2024Review
- Epigenetic changes in sperm are associated with paternal and child quantitative autistic traits in an autism-enriched cohort.Molecular psychiatry · 2024Article
- Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases.Cell communication and signaling : CCS · 2023Review
- Identification and characterization of transcribed enhancers during cerebellar development through enhancer RNA analysis.BMC genomics · 2023Article
- Alzheimer's Disease: From Immune Homeostasis to Neuroinflammatory Condition.International journal of molecular sciences · 2022Review
- Population-level variation in enhancer expression identifies disease mechanisms in the human brain.Nature genetics · 2022Article
- Article
- Detection and identification of cis-regulatory elements using change-point and classification algorithms.BMC genomics · 2022Article
- Current and Future Perspectives of Noncoding RNAs in Brain Function and Neuropsychiatric Disease.Biological psychiatry · 2022Review
- Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders.Computational and structural biotechnology journal · 2022Article
- Genomic Strategies for Understanding the Pathophysiology of Autism Spectrum Disorder.Frontiers in molecular neuroscience · 2022Review
- Evolution of the Human Brain Can Help Determine Pathophysiology of Neurodevelopmental Disorders.Frontiers in neuroscience · 2022Review
- Sex-based eRNA expression and function in ischemic stroke.Neurochemistry international · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite major progress in identifying enhancer regions on a genome-wide scale, the majority of available data are limited to model organisms and human transformed cell lines. We have identified a robust set of enhancer RNAs (eRNAs) expressed in the human brain and constructed networks assessing eRNA-gene coexpression interactions across human fetal brain and multiple adult brain regions. Our data identify brain region-specific eRNAs and show that enhancer regions expressing eRNAs are enriched for genetic variants associated with autism spectrum disorders.
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Registered trials
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