Evidence map›Paper›PMID 26167882›Full record

ArticleNature structural & molecular biology2015

The molecular basis for flexibility in the flexible filamentous plant viruses.

Frank DiMaio, Chun-Chieh Chen, Xiong Yu, Brandon Frenz, Yau-Heiu Hsu, Na-Sheng Lin, Edward H Egelman

Open access · greenAbstract read
In one paragraph

Article in Nature structural & molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
12.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 75 citations in OpenAlex.

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  6. Proviral insights of glycolytic enolase inProceedings of the National Academy of Sciences of the United States of America · 2025
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  14. Article
  15. The evolution of archaeal flagellar filaments.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Article
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  19. Article
  20. NbPsbO1 Interacts Specifically with theJournal of virology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Frank DiMaioDepartment of Biochemistry, University of Washington, Seattle, Washington, USA.
Chun-Chieh Chen1] Institute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan. [2] Molecular and Biological Agricultural Sciences Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan. [3] Graduate Institute of Biotechnology, National Chung-Hsing University, Taichung, Taiwan.ORCID 0000000347992302
Xiong YuDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA.
Brandon FrenzDepartment of Biochemistry, University of Washington, Seattle, Washington, USA.
Yau-Heiu HsuGraduate Institute of Biotechnology, National Chung-Hsing University, Taichung, Taiwan.
Na-Sheng Lin1] Institute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan. [2] Molecular and Biological Agricultural Sciences Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan. [3] Biotechnology Center, National Chung-Hsing University, Taichung, Taiwan.
Edward H EgelmanDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA.
Institute of Plant and Microbial Biology, Academia Sinica · TWUniversity of Virginia · USUniversity of Washington · USNational Chung Hsing University · TW

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Jay William FOX · 1987 to 2026
$72.1M
STRUCTURAL STUDIES OF RECA FILAMENTSR01GM035269 · NIGMS · YALE UNIVERSITY · PI EGELMAN, EDWARD H. · 1986 to 2016
$5.2M
Molecular Electron Microscopy Core Facility ImprovementsG20RR031199 · NCRR · UNIVERSITY OF VIRGINIA · PI SHUPNIK, MARGARET A · 2010 to 2010
$2.0M
300 keV Liquid Helium Robotic MicroscopeS10RR025067 · NCRR · UNIVERSITY OF VIRGINIA · PI EGELMAN, EDWARD H. · 2009 to 2009
$2.0M
Direct Electron Detector for a Titan Krios Robotic Electron Cryo-MicroscopeS10OD018149 · OD · UNIVERSITY OF VIRGINIA · PI EGELMAN, EDWARD H., YEAGER, MARK JAY · 2014 to 2014
$500k
NCI NIH HHS P30 CA044579NCRR NIH HHS G20-RR31199NCRR NIH HHS S10-RR025067NIGMS NIH HHS GM035269NIGMS NIH HHS R01 GM035269NIH HHS S10-OD018149
6 · The paper itself

Abstract

Flexible filamentous plant viruses cause more than half the viral crop damage in the world but are also potentially useful for biotechnology. Structural studies began more than 75 years ago but have failed, owing to the virion's extreme flexibility. We have used cryo-EM to generate an atomic model for bamboo mosaic virus, which reveals flexible N- and C-terminal extensions that allow deformation while still maintaining structural integrity.

Indexed as

BambusaCapsidCapsid ProteinsCryoelectron MicroscopyCrystallography, X-RayModels, MolecularMosaic VirusesProtein BindingProtein Structure, SecondaryProtein Structure, TertiaryRNA, ViralVirionCapsid ProteinsRNA, Viral

Identifiers

PMID26167882
PMCPMC4527879
OpenAlexW1491058174

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.