Evidence map›Paper›PMID 26167518›Full record

ArticleTechnology2015

Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution of

O B Usta, W J McCarty, S Bale, M Hegde, R Jindal, A Bhushan, I Golberg, M L Yarmush

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Technology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
  2. In vitro liver models for toxicological research.Drug metabolism and pharmacokinetics · 2025
    Review
  3. Review
  4. Review
  5. Evaluation of drug carrier hepatotoxicity using primary cell culture models.Nanomedicine : nanotechnology, biology, and medicine · 2023
    Article
  6. Article
  7. Drug metabolism and disposition: the biological fate of chemicals · 2022
    Article
  8. Review
  9. Article
  10. Review
  11. Computational toxicology (Amsterdam, Netherlands) · 2021
    Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

O B UstaCenter for Engineering in Medicine at Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, 51 Blossom St., Boston, MA 02114, USA.
W J McCartyCenter for Engineering in Medicine at Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, 51 Blossom St., Boston, MA 02114, USA.
S BaleCenter for Engineering in Medicine at Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, 51 Blossom St., Boston, MA 02114, USA.
M HegdeCenter for Engineering in Medicine at Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, 51 Blossom St., Boston, MA 02114, USA.
R JindalCenter for Engineering in Medicine at Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, 51 Blossom St., Boston, MA 02114, USA.
A BhushanCenter for Engineering in Medicine at Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, 51 Blossom St., Boston, MA 02114, USA.
I GolbergCenter for Engineering in Medicine at Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, 51 Blossom St., Boston, MA 02114, USA.
M L YarmushCenter for Engineering in Medicine at Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, 51 Blossom St., Boston, MA 02114, USA ; Department of Biomedical Engineering, Rutgers University, 599 Taylor Rd., Piscataway, NJ 08854, USA.

Funding

Collaborations to Extend the Microphysiology Database for Multiple Organ Models,UH2TR000503 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TAYLOR, D. LANSING, YARMUSH, MARTIN L · 2012 to 2013
$2.3M
Dynamics of Altered Metabolic States using a Microfluidic Living Cell PlatformR00DK095984 · NIDDK · STATE UNIVERSITY OF NY,BINGHAMTON · PI BHUSHAN, ABHINAV · 2015 to 2017
$717k
Novel Microfluidic Platforms for Actively Controlled in-vitro Liver ZonationR21EB020192 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI USTA, OSMAN BERK · 2015 to 2016
$479k
Dynamics of Altered Metabolic States using a Microfluidic Living Cell PlatformK99DK095984 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BHUSHAN, ABHINAV · 2013 to 2014
$180k
Hepatic zonation in a microfluidic liver model: application to drug metabolismF32DK098905 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MCCARTY, WILLIAM JOSEPH · 2013 to 2015
$162k
NCATS NIH HHS UH2 TR000503NIDDK NIH HHS F32 DK098905NIDDK NIH HHS K99 DK095984NIDDK NIH HHS R00 DK095984
6 · The paper itself

Abstract

The liver performs many key functions, the most prominent of which is serving as the metabolic hub of the body. For this reason, the liver is the focal point of many investigations aimed at understanding an organism's toxicological response to endogenous and exogenous challenges. Because so many drug failures have involved direct liver toxicity or other organ toxicity from liver generated metabolites, the pharmaceutical industry has constantly sought superior, predictive

Identifiers

PMID26167518
PMCPMC4494128

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.